Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | nitric oxide synthase 2, inducible | Starlite/ChEMBL | References |
Rattus norvegicus | Nitric-oxide synthase, brain | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0037 | 0.3805 | 0.2407 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0023 | 0 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0059 | 1 | 1 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0059 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0059 | 1 | 1 |
Chlamydia trachomatis | sulfite reductase | 0.0037 | 0.3805 | 0.5 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0059 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0059 | 1 | 1 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0059 | 1 | 1 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0059 | 1 | 1 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0052 | 0.8159 | 0.5 |
Brugia malayi | FAD binding domain containing protein | 0.0037 | 0.3805 | 0.3805 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0059 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0029 | 0.1841 | 0.5 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0023 | 0 | 0.5 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0059 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0037 | 0.3805 | 0.3805 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0052 | 0.8159 | 0.8159 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0059 | 1 | 0.5 |
Plasmodium vivax | flavodoxin domain containing protein | 0.0052 | 0.8159 | 0.8159 |
Onchocerca volvulus | 0.0047 | 0.6661 | 0.5 | |
Leishmania major | p450 reductase, putative | 0.0059 | 1 | 1 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0059 | 1 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0059 | 1 | 1 |
Trypanosoma cruzi | p450 reductase, putative | 0.0059 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0029 | 0.1841 | 0.5 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0059 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0023 | 0 | 0.5 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0059 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0059 | 1 | 1 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.003 | 0.1964 | 0.0151 |
Giardia lamblia | Hypothetical protein | 0.0052 | 0.8159 | 0.5 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0059 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0059 | 1 | 1 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0059 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0059 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 1 | 1 |
Treponema pallidum | flavodoxin | 0.0023 | 0 | 0.5 |
Leishmania major | cytochrome P450 reductase, putative | 0.0052 | 0.8159 | 0.8159 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.05 uM | Inhibitory activity against Neuronal Nitric Oxide Synthase (nNOS) | ChEMBL. | 12699384 |
Ki (binding) | = 0.05 uM | Inhibitory activity against neuronal nitric oxide synthase | ChEMBL. | 14667223 |
Ki (binding) | = 0.05 uM | Inhibitory activity against Neuronal Nitric Oxide Synthase (nNOS) | ChEMBL. | 12699384 |
Ki (binding) | = 0.05 uM | Inhibition of rat nNOS | ChEMBL. | 23458846 |
Ki (binding) | = 3.15 uM | Inhibitory activity against Inducible nitric oxide synthase | ChEMBL. | 14667223 |
Ki (binding) | = 3.51 uM | Inhibitory activity against Inducible nitric oxide synthase (iNOS) | ChEMBL. | 12699384 |
Ki (binding) | = 3.51 uM | Inhibitory activity against Inducible nitric oxide synthase (iNOS) | ChEMBL. | 12699384 |
Ki (binding) | = 105 uM | Inhibitory activity against endothelial nitric oxide synthase (eNOS) | ChEMBL. | 12699384 |
Ki (binding) | = 105 uM | Inhibitory activity against endothelial nitric oxide synthase (eNOS) | ChEMBL. | 14667223 |
Ki (binding) | = 105 uM | Inhibitory activity against endothelial nitric oxide synthase (eNOS) | ChEMBL. | 12699384 |
Selectivity (binding) | = 70.2 | Selectivity ratio of Ki value of iNOS to nNOS | ChEMBL. | 12699384 |
Selectivity (binding) | = 70.2 | Selectivity for neuronal over Inducible nitric oxide synthase | ChEMBL. | 14667223 |
Selectivity (binding) | = 2121 | Selectivity ratio of Ki value of eNOS to nNOS | ChEMBL. | 12699384 |
Selectivity (binding) | = 2121 | Selectivity for neuronal over endothelial nitric oxide synthase | ChEMBL. | 14667223 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.