Detailed information for compound 66160

Basic information

Technical information
  • TDR Targets ID: 66160
  • Name: 4-(2-methoxyphenyl)-2,2-dimethyl-5-(4-methyls ulfonylphenyl)furan-3-one
  • MW: 372.435 | Formula: C20H20O5S
  • H donors: 0 H acceptors: 3 LogP: 3.13 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccccc1C1=C(OC(C1=O)(C)C)c1ccc(cc1)S(=O)(=O)C
  • InChi: 1S/C20H20O5S/c1-20(2)19(21)17(15-7-5-6-8-16(15)24-3)18(25-20)13-9-11-14(12-10-13)26(4,22)23/h5-12H,1-4H3
  • InChiKey: CUYNUHPIHNKVRK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-(2-methoxyphenyl)-2,2-dimethyl-5-(4-methylsulfonylphenyl)-3-furanone
  • 5-(4-mesylphenyl)-4-(2-methoxyphenyl)-2,2-dimethyl-furan-3-one

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus prostaglandin-endoperoxide synthase 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus g protein coupled receptor 0.0051 0.0239 0.0429
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0096 0.0773 0.2361
Brugia malayi hypothetical protein 0.0051 0.0239 0.0537
Echinococcus granulosus receptor type guanylyl cyclase 0.0038 0.007 0.0126
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0051 0.0239 0.0239
Loa Loa (eye worm) hypothetical protein 0.0051 0.0239 0.0429
Echinococcus granulosus glutamate receptor 2 0.0038 0.007 0.0126
Brugia malayi hypothetical protein 0.0038 0.007 0.0157
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0454 0.5115 1
Entamoeba histolytica hypothetical protein 0.0038 0.007 0.5
Loa Loa (eye worm) hypothetical protein 0.0038 0.007 0.0126
Echinococcus granulosus orexin receptor type 2 0.0051 0.0239 0.0429
Echinococcus granulosus tm gpcr rhodopsin 0.0051 0.0239 0.0429
Schistosoma mansoni hypothetical protein 0.0051 0.0239 0.0467
Echinococcus granulosus GPCR family 3 C terminal 0.0065 0.04 0.0719
Brugia malayi Serotonin receptor 0.0051 0.0239 0.0537
Schistosoma mansoni alpha-1 adrenergic receptor 0.0051 0.0239 0.0467
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0051 0.0239 0.0429
Loa Loa (eye worm) hypothetical protein 0.0051 0.0239 0.0429
Schistosoma mansoni histamine h1 receptor 0.0051 0.0239 0.0467
Schistosoma mansoni hypothetical protein 0.0051 0.0239 0.0467
Loa Loa (eye worm) hypothetical protein 0.0051 0.0239 0.0429
Loa Loa (eye worm) hypothetical protein 0.0051 0.0239 0.0429
Leishmania major cathepsin L-like protease 0.0072 0.0485 0.5899
Onchocerca volvulus 0.0051 0.0239 0.5973
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0222 0.0498
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0051 0.0239 0.0467
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0051 0.0239 0.0537
Echinococcus granulosus nmda type glutamate receptor 0.0038 0.007 0.0126
Schistosoma mansoni myosin xvIII 0.0051 0.0239 0.0467
Brugia malayi G protein-coupled receptor 0.0051 0.0239 0.0537
Schistosoma mansoni adenoreceptor 0.0051 0.0239 0.0467
Brugia malayi neuropeptide F receptor 0.0051 0.0239 0.0537
Echinococcus multilocularis rhodopsin orphan GPCR 0.0051 0.0239 0.0239
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.003 0.0067
Brugia malayi Dopamine receptor protein 2 0.0051 0.0239 0.0537
Echinococcus multilocularis neuropeptide receptor 0.0051 0.0239 0.0239
Schistosoma mansoni neuropeptide f receptor 76f 0.0051 0.0239 0.0467
Echinococcus granulosus 7tm_1 domain containing protein 0.0051 0.0239 0.0429
Loa Loa (eye worm) G-protein coupled receptor 0.0051 0.0239 0.0429
Onchocerca volvulus 0.0051 0.0239 0.5973
Echinococcus granulosus g protein coupled receptor 0.0051 0.0239 0.0429
Echinococcus multilocularis neuropeptide receptor A26 0.0051 0.0239 0.0239
Echinococcus multilocularis rhodopsin orphan GPCR 0.0051 0.0239 0.0239
Schistosoma mansoni tyrosine kinase 0.0038 0.007 0.0137
Brugia malayi cathepsin B-like cysteine proteinase 0.0283 0.3049 0.6847
Onchocerca volvulus 0.0051 0.0239 0.5973
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0051 0.0239 0.0467
Echinococcus multilocularis rhodopsin orphan GPCR 0.0051 0.0239 0.0239
Loa Loa (eye worm) hypothetical protein 0.0051 0.0239 0.0429
Loa Loa (eye worm) hypothetical protein 0.0051 0.0239 0.0429
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0051 0.0239 0.0467
Echinococcus multilocularis neuropeptide s receptor 0.0051 0.0239 0.0239
Echinococcus granulosus g protein coupled receptor 0.0051 0.0239 0.0429
Brugia malayi metabotropic glutamate receptor type 2 0.0195 0.1973 0.4431
Echinococcus granulosus rhodopsin orphan GPCR 0.0051 0.0239 0.0429
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0038 0.007 0.0157
Echinococcus multilocularis glutamate receptor 2 0.0038 0.007 0.007
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0051 0.0239 0.0467
Brugia malayi Dopamine receptor protein 1 0.0051 0.0239 0.0537
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0038 0.007 0.007
Onchocerca volvulus 0.0051 0.0239 0.5973
Echinococcus granulosus rhodopsin orphan GPCR 0.0051 0.0239 0.0429
Echinococcus multilocularis rhodopsin orphan GPCR 0.0051 0.0239 0.0239
Brugia malayi G-protein coupled receptor 0.0051 0.0239 0.0537
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0102 0.0855 0.1535
Loa Loa (eye worm) hypothetical protein 0.0051 0.0239 0.0429
Schistosoma mansoni hypothetical protein 0.0034 0.003 0.0059
Echinococcus multilocularis cathepsin b 0.0283 0.3049 0.3049
Loa Loa (eye worm) hypothetical protein 0.0051 0.0239 0.0429
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0065 0.04 0.0899
Leishmania major cathepsin L-like protease 0.0072 0.0485 0.5899
Echinococcus granulosus tyrosine kinase 0.0038 0.007 0.0126
Echinococcus granulosus atrial natriuretic peptide receptor 0.0038 0.007 0.0126
Loa Loa (eye worm) hypothetical protein 0.0038 0.007 0.0126
Loa Loa (eye worm) hypothetical protein 0.0051 0.0239 0.0429
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0386 0.0755
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0051 0.0239 0.0467
Onchocerca volvulus 0.0051 0.0239 0.5973
Onchocerca volvulus 0.0051 0.0239 0.5973
Echinococcus granulosus neuropeptide receptor 0.0051 0.0239 0.0429
Onchocerca volvulus 0.0051 0.0239 0.5973
Loa Loa (eye worm) hypothetical protein 0.0051 0.0239 0.0429
Schistosoma mansoni hypothetical protein 0.0051 0.0239 0.0467
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0051 0.0239 0.0467
Loa Loa (eye worm) glutamate receptor 0.0157 0.1518 0.2725
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0283 0.3049 0.596
Schistosoma mansoni hypothetical protein 0.0051 0.0239 0.0467
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0038 0.007 0.007
Echinococcus multilocularis orexin receptor type 2 0.0051 0.0239 0.0239
Echinococcus granulosus alpha 1A adrenergic receptor 0.0051 0.0239 0.0429
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0051 0.0239 0.0239
Schistosoma mansoni opsin-like receptor 0.0051 0.0239 0.0467
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0051 0.0239 0.0429
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.0485 0.1393
Loa Loa (eye worm) hypothetical protein 0.0102 0.0855 0.1535
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0051 0.0239 0.0429
Giardia lamblia Cathepsin B precursor 0.0096 0.0773 0.5
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0051 0.0239 0.0429
Loa Loa (eye worm) hypothetical protein 0.0283 0.3049 0.5473
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0051 0.0239 0.0429
Onchocerca volvulus 0.0051 0.0239 0.5973
Brugia malayi hypothetical protein 0.0051 0.0239 0.0537
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0491 0.557 0.557
Brugia malayi Metabotropic glutamate receptor precursor. 0.0399 0.4452 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0051 0.0239 0.0467
Echinococcus multilocularis g protein coupled receptor 0.0051 0.0239 0.0239
Loa Loa (eye worm) hypothetical protein 0.0051 0.0239 0.0429
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0051 0.0239 0.0467
Echinococcus granulosus sex peptide receptor 0.0051 0.0239 0.0429
Echinococcus multilocularis neuropeptide Y receptor 0.0051 0.0239 0.0239
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0066 0.0418 0.1169
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0222 0.0498
Loa Loa (eye worm) hypothetical protein 0.0051 0.0239 0.0429
Echinococcus granulosus neuropeptides capa receptor 0.0051 0.0239 0.0429
Echinococcus multilocularis g protein coupled receptor 0.0051 0.0239 0.0239
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0386 0.0386
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0051 0.0239 0.0239
Loa Loa (eye worm) hypothetical protein 0.0051 0.0239 0.0429
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0051 0.0239 0.0239
Echinococcus multilocularis fmrfamide receptor 0.0051 0.0239 0.0239
Schistosoma mansoni biogenic amine (5HT) receptor 0.0051 0.0239 0.0467
Loa Loa (eye worm) hypothetical protein 0.0038 0.007 0.0126
Giardia lamblia Cathepsin B precursor 0.0096 0.0773 0.5
Brugia malayi hypothetical protein 0.0051 0.0239 0.0537
Loa Loa (eye worm) hypothetical protein 0.0051 0.0239 0.0429
Brugia malayi putative neuropeptide receptor NPR1 0.0051 0.0239 0.0537
Loa Loa (eye worm) melatonin receptor type 1A 0.0051 0.0239 0.0429
Echinococcus granulosus peptide allatostatin:somatostatin 0.0051 0.0239 0.0429
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0051 0.0239 0.0537
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0096 0.0773 0.1512
Brugia malayi Receptor family ligand binding region containing protein 0.0038 0.007 0.0157
Brugia malayi RE15519p 0.0051 0.0239 0.0537
Echinococcus granulosus tm gpcr rhodopsin 0.0051 0.0239 0.0429
Loa Loa (eye worm) hypothetical protein 0.0038 0.007 0.0126
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0051 0.0239 0.0467
Echinococcus granulosus neuropeptide Y receptor 0.0051 0.0239 0.0429
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0038 0.007 0.0126
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0051 0.0239 0.0239
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0102 0.0855 0.1535
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0051 0.0239 0.0467
Loa Loa (eye worm) RGC/RGC protein kinase 0.0038 0.007 0.0126
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0051 0.0239 0.0239
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0051 0.0239 0.0467
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0038 0.007 0.0126
Echinococcus granulosus rhodopsin orphan GPCR 0.0051 0.0239 0.0429
Echinococcus multilocularis serotonin receptor 0.0051 0.0239 0.0239
Echinococcus multilocularis allatostatin A receptor 0.0051 0.0239 0.0239
Echinococcus granulosus glutamate receptor 2 0.0038 0.007 0.0126
Brugia malayi G-protein coupled receptor 0.0051 0.0239 0.0537
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0051 0.0239 0.0467
Echinococcus multilocularis somatostatin receptor 0.0051 0.0239 0.0239
Echinococcus multilocularis receptor type guanylyl cyclase 0.0038 0.007 0.007
Echinococcus multilocularis GPCR, family 3, C terminal 0.0065 0.04 0.04
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0283 0.3049 0.596
Echinococcus granulosus rhodopsin orphan GPCR 0.0051 0.0239 0.0429
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0051 0.0239 0.0467
Echinococcus multilocularis neuropeptide FF receptor 2 0.0051 0.0239 0.0239
Schistosoma mansoni amine GPCR 0.0051 0.0239 0.0467
Brugia malayi TAR-binding protein 0.0064 0.0386 0.0867
Schistosoma mansoni amine GPCR 0.0051 0.0239 0.0467
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0051 0.0239 0.0239
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0051 0.0239 0.0429
Loa Loa (eye worm) hypothetical protein 0.0038 0.007 0.0126
Brugia malayi Dopamine receptor 0.0051 0.0239 0.0537
Loa Loa (eye worm) hypothetical protein 0.0051 0.0239 0.0429
Loa Loa (eye worm) hypothetical protein 0.005 0.0222 0.0398
Loa Loa (eye worm) hypothetical protein 0.0051 0.0239 0.0429
Loa Loa (eye worm) cathepsin B 0.0096 0.0773 0.1388
Onchocerca volvulus 0.0051 0.0239 0.5973
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0051 0.0239 0.0239
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0386 0.0693
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0362 0.3997 0.8978
Schistosoma mansoni neuropeptide F-like receptor 0.0051 0.0239 0.0467
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0051 0.0239 0.0239
Onchocerca volvulus 0.0038 0.007 0.175
Onchocerca volvulus Neuropeptide F receptor homolog 0.0051 0.0239 0.5973
Echinococcus granulosus neuropeptide FF receptor 2 0.0051 0.0239 0.0429
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0051 0.0239 0.0467
Schistosoma mansoni metabotropic glutamate receptor 0.0195 0.1973 0.3857
Brugia malayi RNA binding protein 0.0064 0.0386 0.0867
Onchocerca volvulus 0.0051 0.0239 0.5973
Brugia malayi ORL1-like opioid receptor 0.0051 0.0239 0.0537
Brugia malayi hypothetical protein 0.0051 0.0239 0.0537
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0386 0.0755
Echinococcus multilocularis tyrosine kinase 0.0038 0.007 0.007
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0038 0.007 0.007
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0051 0.0239 0.0429
Echinococcus multilocularis dro:myosuppressin receptor 0.0051 0.0239 0.0239
Brugia malayi hypothetical protein 0.0051 0.0239 0.0537
Loa Loa (eye worm) hypothetical protein 0.0034 0.003 0.0054
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0051 0.0239 0.0467
Echinococcus multilocularis rhodopsin orphan GPCR 0.0051 0.0239 0.0239
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0334 0.3667 0.3667
Loa Loa (eye worm) hypothetical protein 0.0051 0.0239 0.0429
Onchocerca volvulus 0.0051 0.0239 0.5973
Echinococcus granulosus metabotropic glutamate receptor 2 0.0334 0.3667 0.6584
Echinococcus granulosus neuropeptide receptor A26 0.0051 0.0239 0.0429
Loa Loa (eye worm) RGC/RGC protein kinase 0.0038 0.007 0.0126
Schistosoma mansoni amine GPCR 0.0051 0.0239 0.0467
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0051 0.0239 0.0239
Echinococcus granulosus 7TM GPCR rhodopsin 0.0051 0.0239 0.0429
Loa Loa (eye worm) hypothetical protein 0.0051 0.0239 0.0429
Brugia malayi hypothetical protein 0.0051 0.0239 0.0537
Loa Loa (eye worm) neuropeptide F receptor 0.0051 0.0239 0.0429
Loa Loa (eye worm) hypothetical protein 0.0065 0.04 0.0719
Loa Loa (eye worm) hypothetical protein 0.0051 0.0239 0.0429
Echinococcus granulosus tar DNA binding protein 0.0064 0.0386 0.0693
Echinococcus granulosus hypothetical protein 0.0051 0.0239 0.0429
Brugia malayi Melatonin receptor type 1A 0.0051 0.0239 0.0537
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0038 0.007 0.007
Brugia malayi follicle stimulating hormone receptor 0.0051 0.0239 0.0537
Onchocerca volvulus 0.0051 0.0239 0.5973
Echinococcus multilocularis neuropeptides capa receptor 0.0051 0.0239 0.0239
Schistosoma mansoni biogenic amine receptor 0.0051 0.0239 0.0467
Schistosoma mansoni growth hormone secretagogue receptor 0.0051 0.0239 0.0467
Echinococcus granulosus cathepsin b 0.0283 0.3049 0.5473
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0386 0.0755
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0222 0.0398
Echinococcus granulosus g-protein coupled receptor 0.0051 0.0239 0.0429
Loa Loa (eye worm) hypothetical protein 0.0051 0.0239 0.0429
Loa Loa (eye worm) hypothetical protein 0.0051 0.0239 0.0429
Echinococcus granulosus neuropeptide Y receptor 0.0051 0.0239 0.0429
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0038 0.007 0.007
Loa Loa (eye worm) glutamate receptor 0.0399 0.4452 0.7993
Giardia lamblia Cathepsin B precursor 0.0096 0.0773 0.5
Onchocerca volvulus 0.0051 0.0239 0.5973
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0038 0.007 0.0126
Onchocerca volvulus 0.0038 0.007 0.175
Loa Loa (eye worm) hypothetical protein 0.0051 0.0239 0.0429
Schistosoma mansoni neuropeptide receptor 0.0051 0.0239 0.0467
Loa Loa (eye worm) hypothetical protein 0.0051 0.0239 0.0429
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0283 0.3049 0.596
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0051 0.0239 0.0429
Echinococcus granulosus neuropeptide receptor 0.0051 0.0239 0.0429
Loa Loa (eye worm) hypothetical protein 0.0051 0.0239 0.0429
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0051 0.0239 0.0467
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0283 0.3049 0.596
Schistosoma mansoni hypothetical protein 0.0065 0.04 0.0783
Brugia malayi AKH receptor 0.0051 0.0239 0.0537
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0051 0.0239 0.0239
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0051 0.0239 0.0429
Echinococcus multilocularis neuropeptide receptor 0.0051 0.0239 0.0239
Loa Loa (eye worm) hypothetical protein 0.0051 0.0239 0.0429
Echinococcus granulosus tm gpcr rhodopsin 0.0051 0.0239 0.0429
Loa Loa (eye worm) hypothetical protein 0.0051 0.0239 0.0429
Schistosoma mansoni biogenic amine receptor 0.0051 0.0239 0.0467
Schistosoma mansoni glutamate receptor NMDA 0.0038 0.007 0.0137
Echinococcus granulosus neuropeptides capa receptor 0.0051 0.0239 0.0429
Loa Loa (eye worm) hypothetical protein 0.0051 0.0239 0.0429
Echinococcus multilocularis G-protein coupled receptor, putative 0.0051 0.0239 0.0239
Schistosoma mansoni neuropeptide receptor 0.0051 0.0239 0.0467
Loa Loa (eye worm) hypothetical protein 0.0051 0.0239 0.0429
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0051 0.0239 0.0537
Brugia malayi putative neuropeptide receptor 0.0051 0.0239 0.0537
Echinococcus granulosus serotonin receptor 0.0051 0.0239 0.0429
Echinococcus multilocularis g-protein coupled receptor 0.0051 0.0239 0.0239
Loa Loa (eye worm) RNA binding protein 0.0064 0.0386 0.0693
Loa Loa (eye worm) hypothetical protein 0.0051 0.0239 0.0429
Echinococcus granulosus cathepsin b 0.0283 0.3049 0.5473
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0051 0.0239 0.0467
Loa Loa (eye worm) hypothetical protein 0.0051 0.0239 0.0429
Echinococcus multilocularis fmrfamide receptor 0.0051 0.0239 0.0239
Brugia malayi Serotonin receptor 0.0051 0.0239 0.0537
Echinococcus granulosus biogenic amine 5HT receptor 0.0051 0.0239 0.0429
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.0065 0.04 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0051 0.0239 0.0537
Brugia malayi G protein-coupled receptor F59B2.13 0.0051 0.0239 0.0537
Loa Loa (eye worm) RGC/RGC protein kinase 0.0038 0.007 0.0126
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0386 0.0867
Loa Loa (eye worm) hypothetical protein 0.0051 0.0239 0.0429
Loa Loa (eye worm) hypothetical protein 0.0051 0.0239 0.0429
Loa Loa (eye worm) hypothetical protein 0.0051 0.0239 0.0429
Loa Loa (eye worm) G-protein coupled receptor 0.0051 0.0239 0.0429
Schistosoma mansoni neuropeptide F-like receptor 0.0051 0.0239 0.0467
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0096 0.0773 1
Echinococcus granulosus somatostatin receptor 0.0051 0.0239 0.0429
Trypanosoma brucei cysteine peptidase C (CPC) 0.0096 0.0773 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0051 0.0239 0.0429
Schistosoma mansoni metabotropic glutamate receptor 0.0334 0.3667 0.7169
Loa Loa (eye worm) TYRA-2 protein 0.0051 0.0239 0.0429
Echinococcus granulosus metabotropic glutamate receptor 5 0.0491 0.557 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0239 0.0429
Schistosoma mansoni biogenic amine (5HT) receptor 0.0051 0.0239 0.0467
Echinococcus granulosus biogenic amine 5HT receptor 0.0051 0.0239 0.0429
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0038 0.007 0.0126
Loa Loa (eye worm) hypothetical protein 0.0491 0.557 1
Brugia malayi neuropeptide F receptor 0.0051 0.0239 0.0537
Echinococcus multilocularis G protein coupled receptor 139 0.0051 0.0239 0.0239
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0051 0.0239 0.0239
Echinococcus granulosus neuropeptide s receptor 0.0051 0.0239 0.0429
Onchocerca volvulus 0.0051 0.0239 0.5973
Echinococcus multilocularis neuropeptides capa receptor 0.0051 0.0239 0.0239
Onchocerca volvulus 0.0051 0.0239 0.5973
Loa Loa (eye worm) neuropeptide F receptor 0.0051 0.0239 0.0429
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0051 0.0239 0.0537
Echinococcus granulosus rhodopsin orphan GPCR 0.0051 0.0239 0.0429
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0038 0.007 0.0126
Brugia malayi hypothetical protein 0.0051 0.0239 0.0537
Onchocerca volvulus 0.0051 0.0239 0.5973
Schistosoma mansoni opsin-like receptor 0.0051 0.0239 0.0467
Onchocerca volvulus 0.0051 0.0239 0.5973
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0051 0.0239 0.5973
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0283 0.3049 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0051 0.0239 0.0239
Brugia malayi Receptor family ligand binding region containing protein 0.0102 0.0855 0.1921
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0051 0.0239 0.0467
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0038 0.007 0.175
Schistosoma mansoni neuropeptide receptor 0.0051 0.0239 0.0467
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0386 0.0755
Loa Loa (eye worm) hypothetical protein 0.0051 0.0239 0.0429
Schistosoma mansoni biogenic amine receptor 0.0051 0.0239 0.0467
Brugia malayi sulfakinin receptor protein 0.0051 0.0239 0.0537
Loa Loa (eye worm) hypothetical protein 0.0051 0.0239 0.0429
Loa Loa (eye worm) hypothetical protein 0.0051 0.0239 0.0429
Brugia malayi hypothetical protein 0.0051 0.0239 0.0537
Echinococcus multilocularis glutamate receptor 2 0.0038 0.007 0.007
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0051 0.0239 0.0467
Echinococcus multilocularis nmda type glutamate receptor 0.0038 0.007 0.007
Echinococcus granulosus dro:myosuppressin receptor 0.0051 0.0239 0.0429
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0051 0.0239 0.0239
Echinococcus multilocularis rhodopsin orphan GPCR 0.0051 0.0239 0.0239
Echinococcus granulosus fmrfamide receptor 0.0051 0.0239 0.0429
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0051 0.0239 0.0429
Echinococcus multilocularis rhodopsin orphan GPCR 0.0051 0.0239 0.0239
Toxoplasma gondii cathepsin B 0.0096 0.0773 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0051 0.0239 0.0467
Brugia malayi larval opioid receptor 0.0051 0.0239 0.0537
Loa Loa (eye worm) hypothetical protein 0.0038 0.007 0.0126
Loa Loa (eye worm) hypothetical protein 0.0051 0.0239 0.0429
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0051 0.0239 0.0537
Echinococcus granulosus rhodopsin orphan GPCR 0.0051 0.0239 0.0429
Schistosoma mansoni protein kinase 0.0038 0.007 0.0137
Onchocerca volvulus Poor gastrulation protein homolog 0.0065 0.04 1
Brugia malayi GnHR receptor homolog 0.0051 0.0239 0.0537
Echinococcus multilocularis neuropeptide Y receptor 0.0051 0.0239 0.0239
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.0485 0.1393
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.0485 0.1393
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0051 0.0239 0.0429
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0051 0.0239 0.0467
Loa Loa (eye worm) hypothetical protein 0.0051 0.0239 0.0429
Loa Loa (eye worm) hypothetical protein 0.0051 0.0239 0.0429
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0386 0.0755
Echinococcus granulosus rhodopsin orphan GPCR 0.0051 0.0239 0.0429
Schistosoma mansoni opsin-like receptor 0.0051 0.0239 0.0467
Loa Loa (eye worm) hypothetical protein 0.0051 0.0239 0.0429
Echinococcus granulosus G protein coupled receptor 139 0.0051 0.0239 0.0429
Leishmania major cathepsin L-like protease 0.0072 0.0485 0.5899
Loa Loa (eye worm) hypothetical protein 0.0038 0.007 0.0126
Loa Loa (eye worm) hypothetical protein 0.0051 0.0239 0.0429
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0051 0.0239 0.0239
Loa Loa (eye worm) hypothetical protein 0.0051 0.0239 0.0429
Brugia malayi Guanylyl cyclase protein 23 0.0038 0.007 0.0157
Schistosoma mansoni neuropeptide receptor 0.0051 0.0239 0.0467
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0051 0.0239 0.0467
Brugia malayi hypothetical protein 0.0051 0.0239 0.0537
Loa Loa (eye worm) hypothetical protein 0.0051 0.0239 0.0429
Trypanosoma cruzi cruzipain precursor, putative 0.0072 0.0485 0.1393
Schistosoma mansoni tyrosine kinase 0.0038 0.007 0.0137
Brugia malayi hypothetical protein 0.0051 0.0239 0.0537
Schistosoma mansoni amine GPCR 0.0051 0.0239 0.0467
Echinococcus granulosus allatostatin A receptor 0.0051 0.0239 0.0429
Echinococcus multilocularis sex peptide receptor 0.0051 0.0239 0.0239
Echinococcus multilocularis serotonin receptor 0.0051 0.0239 0.0239
Schistosoma mansoni amine GPCR 0.0051 0.0239 0.0467
Echinococcus multilocularis g protein coupled receptor 0.0051 0.0239 0.0239
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0096 0.0773 0.5
Echinococcus multilocularis cathepsin b 0.0283 0.3049 0.3049
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0386 0.0693
Trypanosoma cruzi major cysteine proteinase, putative 0.0058 0.0321 0.0841
Loa Loa (eye worm) hypothetical protein 0.0051 0.0239 0.0429

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.1 ug ml-1 Ability to inhibit Prostaglandin G/H synthase 2 by using freshly harvested mouse peritoneal macrophages ChEMBL. 11206450
IC50 (binding) = 0.1 ug ml-1 Ability to inhibit Prostaglandin G/H synthase 2 by using freshly harvested mouse peritoneal macrophages ChEMBL. 11206450
IC50 (binding) = 0.1 ug ml-1 Inhibition of COX2 in C57BL/6 mouse peritoneal macrophages assessed as reduction in PGE2 formation pre-incubated for 2 hrs before LPS stimulation for 16 hrs followed by arachidonic acid addition and measured after 10 mins in presence of 500 uM aspirin by radio-immuno assay or enzyme-immunoassay PATENT. No reference
IC50 (binding) = 50 ug ml-1 Ability to inhibit Prostaglandin G/H synthase 1 by using freshly harvested mouse peritoneal macrophages ChEMBL. 11206450
IC50 (binding) = 50 ug ml-1 Ability to inhibit Prostaglandin G/H synthase 1 by using freshly harvested mouse peritoneal macrophages ChEMBL. 11206450
IC50 (binding) = 50 ug ml-1 Inhibition of COX1 in C57BL/6 mouse peritoneal macrophages assessed as reduction in PGE2 formation pre-incubated for 2 hrs followed by arachidonic acid addition and measured after 10 mins by radio-immuno assay or enzyme-immunoassay PATENT. No reference
Selectivity (binding) = 500 Tested for COX-2 selectivity over COX-1 using freshly harvested mouse peritoneal macrophages ChEMBL. 11206450
Selectivity (binding) = 500 Tested for COX-2 selectivity over COX-1 using freshly harvested mouse peritoneal macrophages ChEMBL. 11206450

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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