Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | glutaminase 2 | 0.0267 | 1 | 1 |
Mycobacterium ulcerans | glutaminase | 0.0267 | 1 | 0.5 |
Echinococcus granulosus | polyADP ribose glycohydrolase | 0.0152 | 0.4241 | 0.5 |
Trypanosoma cruzi | poly(ADP-ribose) glycohydrolase, putative | 0.0152 | 0.4241 | 0.5 |
Schistosoma mansoni | poly(ADP-ribose) glycohydrolase | 0.0152 | 0.4241 | 0.1323 |
Trypanosoma cruzi | poly(ADP-ribose) glycohydrolase, putative | 0.0152 | 0.4241 | 0.5 |
Echinococcus multilocularis | poly(ADP ribose) glycohydrolase | 0.0152 | 0.4241 | 0.5 |
Toxoplasma gondii | poly(ADP-ribose) glycohydrolase | 0.0152 | 0.4241 | 1 |
Schistosoma mansoni | glutaminase | 0.0267 | 1 | 1 |
Trypanosoma brucei | poly(ADP-ribose) glycohydrolase, putative | 0.0152 | 0.4241 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0152 | 0.4241 | 1 |
Trichomonas vaginalis | glutaminase, putative | 0.0267 | 1 | 0.5 |
Loa Loa (eye worm) | glutaminase | 0.0267 | 1 | 1 |
Entamoeba histolytica | poly(ADP-ribose) glycohydrolase, putative | 0.0152 | 0.4241 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.