Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0079 | 0.3455 | 1 |
Onchocerca volvulus | 0.0031 | 0 | 0.5 | |
Onchocerca volvulus | 0.0031 | 0 | 0.5 | |
Echinococcus multilocularis | sodium channel protein | 0.0081 | 0.3546 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.007 | 0.2752 | 0.5 |
Onchocerca volvulus | 0.0031 | 0 | 0.5 | |
Onchocerca volvulus | 0.0031 | 0 | 0.5 | |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0079 | 0.3455 | 0.9743 |
Onchocerca volvulus | 0.0031 | 0 | 0.5 | |
Onchocerca volvulus | 0.0031 | 0 | 0.5 | |
Onchocerca volvulus | 0.0031 | 0 | 0.5 | |
Onchocerca volvulus | 0.0031 | 0 | 0.5 | |
Onchocerca volvulus | 0.0031 | 0 | 0.5 | |
Echinococcus granulosus | sodium channel protein | 0.0081 | 0.3546 | 1 |
Onchocerca volvulus | 0.0031 | 0 | 0.5 | |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0079 | 0.3455 | 0.9743 |
Onchocerca volvulus | 0.0031 | 0 | 0.5 | |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0031 | 0 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0086 | 0.3945 | 1 |
Onchocerca volvulus | 0.0031 | 0 | 0.5 | |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0031 | 0 | 0.5 |
Onchocerca volvulus | 0.0031 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 1 | 1 |
Onchocerca volvulus | 0.0031 | 0 | 0.5 | |
Onchocerca volvulus | 0.0031 | 0 | 0.5 | |
Onchocerca volvulus | 0.0031 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0086 | 0.3945 | 1 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.0171 | 1 | 1 |
Leishmania major | calcium channel protein, putative,ion transporter, putative | 0.0081 | 0.3546 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0171 | 1 | 0.5 |
Onchocerca volvulus | 0.0031 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.2749 | 0.2749 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0079 | 0.3455 | 0.3455 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.007 | 0.2752 | 0.5 |
Echinococcus granulosus | voltage gated sodium channel Nav1 alpha subunit | 0.0081 | 0.3546 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.