Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | calcium channel protein, putative,ion transporter, putative | 0.0044 | 0.0441 | 0.5 |
Echinococcus multilocularis | potassium voltage gated channel subfamily A | 0.0087 | 0.7858 | 0.8403 |
Echinococcus granulosus | potassium voltage gated channel subfamily A | 0.0096 | 0.9351 | 1 |
Echinococcus multilocularis | shaker cognate | 0.0053 | 0.1877 | 0.2007 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0084 | 0.7328 | 0.7743 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0096 | 0.9351 | 1 |
Brugia malayi | Voltage-gated potassium channel, Shal-family (KCND, Kv4-like) alpha-subunit. C. elegans shl-1 ortholog | 0.0084 | 0.7328 | 0.7221 |
Echinococcus granulosus | potassium voltage gated channel protein | 0.0053 | 0.1877 | 0.2007 |
Echinococcus granulosus | potassium voltage gated channel protein | 0.0094 | 0.9027 | 0.9654 |
Brugia malayi | Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog | 0.0053 | 0.1877 | 0.1553 |
Echinococcus multilocularis | sodium channel protein | 0.0044 | 0.0441 | 0.0472 |
Echinococcus multilocularis | potassium voltage gated channel protein | 0.0096 | 0.9351 | 1 |
Echinococcus multilocularis | potassium voltage gated channel protein | 0.0094 | 0.9027 | 0.9654 |
Loa Loa (eye worm) | voltage-gated potassium channel | 0.0053 | 0.1877 | 0.1553 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0094 | 0.9027 | 0.9639 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0096 | 0.9351 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.9351 | 0.9325 |
Echinococcus granulosus | sodium channel protein | 0.0044 | 0.0441 | 0.0472 |
Echinococcus multilocularis | potassium voltage gated channel protein | 0.0053 | 0.1877 | 0.2007 |
Echinococcus granulosus | potassium voltage gated channel protein | 0.0096 | 0.9351 | 1 |
Echinococcus granulosus | shaker cognate | 0.0053 | 0.1877 | 0.2007 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0053 | 0.1877 | 0.1665 |
Brugia malayi | Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit | 0.0096 | 0.9351 | 0.9325 |
Echinococcus granulosus | voltage gated sodium channel Nav1 alpha subunit | 0.0044 | 0.0441 | 0.0472 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 20 % | Inhibition of Human Placenta Inner-Ring Iodothyronine 5-deiodinase at the compound concentration of 5 mM | ChEMBL. | 4067996 |
Inhibition (binding) | = 20 % | Inhibition of Human Placenta Inner-Ring Iodothyronine 5-deiodinase at the compound concentration of 5 mM | ChEMBL. | 4067996 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.