Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | calcium channel protein, putative,ion transporter, putative | 0.0051 | 0.0441 | 0.5 |
Echinococcus multilocularis | potassium voltage gated channel subfamily A | 0.0101 | 0.7858 | 0.8403 |
Echinococcus multilocularis | shaker cognate | 0.0061 | 0.1877 | 0.2007 |
Echinococcus granulosus | potassium voltage gated channel subfamily A | 0.0111 | 0.9351 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0097 | 0.7328 | 0.7743 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0111 | 0.9351 | 1 |
Echinococcus granulosus | potassium voltage gated channel protein | 0.0061 | 0.1877 | 0.2007 |
Brugia malayi | Voltage-gated potassium channel, Shal-family (KCND, Kv4-like) alpha-subunit. C. elegans shl-1 ortholog | 0.0097 | 0.7328 | 0.7221 |
Echinococcus granulosus | potassium voltage gated channel protein | 0.0109 | 0.9027 | 0.9654 |
Brugia malayi | Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog | 0.0061 | 0.1877 | 0.1553 |
Echinococcus multilocularis | potassium voltage gated channel protein | 0.0111 | 0.9351 | 1 |
Echinococcus multilocularis | sodium channel protein | 0.0051 | 0.0441 | 0.0472 |
Echinococcus multilocularis | potassium voltage gated channel protein | 0.0109 | 0.9027 | 0.9654 |
Loa Loa (eye worm) | voltage-gated potassium channel | 0.0061 | 0.1877 | 0.1553 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0109 | 0.9027 | 0.9639 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0111 | 0.9351 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.9351 | 0.9325 |
Echinococcus granulosus | sodium channel protein | 0.0051 | 0.0441 | 0.0472 |
Echinococcus multilocularis | potassium voltage gated channel protein | 0.0061 | 0.1877 | 0.2007 |
Echinococcus granulosus | potassium voltage gated channel protein | 0.0111 | 0.9351 | 1 |
Echinococcus granulosus | shaker cognate | 0.0061 | 0.1877 | 0.2007 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0061 | 0.1877 | 0.1665 |
Brugia malayi | Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit | 0.0111 | 0.9351 | 0.9325 |
Echinococcus granulosus | voltage gated sodium channel Nav1 alpha subunit | 0.0051 | 0.0441 | 0.0472 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 5 % | Decrease in developed tension of the right atrium of guinea pig expressed as the negative chronotropy. | ChEMBL. | 10346921 |
Activity (functional) | = 5 % | Percent inhibition of calcium-induced contraction on K+ depolarized guinea pig aortic strip. | ChEMBL. | 10346921 |
Activity (functional) | = 80 % | Decrease in developed tension of the left atrium of guinea pig expressed as the negative inotropy. | ChEMBL. | 10346921 |
Alpha max (functional) | = 0.5 | The efficacy in reverting MDR was evaluated on human erythroleukaemia K-562 cell line | ChEMBL. | 10346921 |
Dead cells (ADMET) | = 3 % | Percentage of the dead cells of K-562 cells was determined for the compound | ChEMBL. | 10346921 |
Dead cells (ADMET) | = 3 % | Percentage of the dead cells of K-562 cells was determined for the compound | ChEMBL. | 10346921 |
EC30 (functional) | 0 uM | Potency expressed as EC30 for the negative chronotropic activity; 'i' means Inactive | ChEMBL. | 10346921 |
EC50 (functional) | = 0.64 uM | Potency expressed as EC50 for the negative inotropic activity. | ChEMBL. | 10346921 |
IC50 (functional) | i 0 uM | Potency expressed as IC50 for the vasorelaxant activity; 'i' means inactive. | ChEMBL. | 10346921 |
Potency (functional) | = 0.5 uM | Potency that causes a half maximal increase in nuclear concentration of pirarubicin. | ChEMBL. | 10346921 |
Potency (functional) | = 0.5 uM | Potency that causes a half maximal increase in nuclear concentration of pirarubicin. | ChEMBL. | 10346921 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 10346921 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.