Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bos taurus | GABA-A receptor; anion channel | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | Cys loop ligand gated ion channel subunit | GABA-A receptor; anion channel | 555 aa | 583 aa | 25.4 % |
Onchocerca volvulus | GABA-A receptor; anion channel | 555 aa | 516 aa | 25.4 % | |
Onchocerca volvulus | GABA-A receptor; anion channel | 555 aa | 466 aa | 31.3 % | |
Echinococcus granulosus | Cys loop ligand gated ion channel subunit | GABA-A receptor; anion channel | 555 aa | 578 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | aminopeptidase n, putative | 0.0039 | 0 | 0.5 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.011 | 0.2129 | 1 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.011 | 0.2129 | 1 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.011 | 0.2129 | 0.2129 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.011 | 0.2129 | 0.2129 |
Plasmodium falciparum | M1-family alanyl aminopeptidase, putative | 0.0039 | 0 | 0.5 |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.011 | 0.2129 | 1 |
Brugia malayi | Peptidase family M1 containing protein | 0.011 | 0.2129 | 0.2129 |
Loa Loa (eye worm) | aminopeptidase N | 0.011 | 0.2129 | 0.2407 |
Schistosoma mansoni | cytosol alanyl aminopeptidase (M01 family) | 0.011 | 0.2129 | 1 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.011 | 0.2129 | 0.2129 |
Brugia malayi | hypothetical protein | 0.011 | 0.2129 | 0.2129 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.011 | 0.2129 | 0.2129 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.011 | 0.2129 | 1 |
Trypanosoma cruzi | aminopeptidase, putative | 0.011 | 0.2129 | 1 |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.011 | 0.2129 | 1 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.011 | 0.2129 | 0.2129 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.011 | 0.2129 | 0.2129 |
Onchocerca volvulus | 0.011 | 0.2129 | 0.2129 | |
Echinococcus multilocularis | Peptidase M1, membrane alanine aminopeptidase, N terminal | 0.011 | 0.2129 | 0.2129 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.011 | 0.2129 | 1 |
Plasmodium vivax | M1-family alanyl aminopeptidase, putative | 0.0039 | 0 | 0.5 |
Onchocerca volvulus | 0.0373 | 1 | 1 | |
Entamoeba histolytica | aminopeptidase, putative | 0.011 | 0.2129 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0263 | 0.6717 | 0.7593 |
Loa Loa (eye worm) | hypothetical protein | 0.0334 | 0.8846 | 1 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0071 | 0.0975 | 0.0975 |
Echinococcus multilocularis | aminopeptidase N | 0.0373 | 1 | 1 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.011 | 0.2129 | 1 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.011 | 0.2129 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0975 | 0.1102 |
Echinococcus granulosus | aminopeptidase N | 0.0373 | 1 | 1 |
Schistosoma mansoni | family M1 non-peptidase homologue (M01 family) | 0.0071 | 0.0975 | 0.4578 |
Plasmodium vivax | M1-family alanyl aminopeptidase, putative | 0.0039 | 0 | 0.5 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.011 | 0.2129 | 0.2129 |
Toxoplasma gondii | aminopeptidase N, putative | 0.0039 | 0 | 0.5 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.011 | 0.2129 | 0.2129 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.011 | 0.2129 | 1 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0302 | 0.7871 | 0.8898 |
Toxoplasma gondii | aminopeptidase N protein | 0.0039 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0975 | 0.1102 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.011 | 0.2129 | 1 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.011 | 0.2129 | 1 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.011 | 0.2129 | 0.2129 |
Trypanosoma cruzi | metallo-peptidase, Clan MA(E) Family M1 | 0.0071 | 0.0975 | 0.4578 |
Plasmodium falciparum | M1-family alanyl aminopeptidase | 0.0039 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.56 uM | Potency related to miltirone (1) at the central benzodiazepine receptor was determined using [3H]-flunitrazepam as radioligand | ChEMBL. | 1851844 |
IC50 (binding) | = 0.56 uM | Potency related to miltirone (1) at the central benzodiazepine receptor was determined using [3H]-flunitrazepam as radioligand | ChEMBL. | 1851844 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.