Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | endothelin receptor type B | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0209 | 0.7295 | 0.8549 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.0076 | 0 | 0.5 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0076 | 0 | 0.5 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0076 | 0 | 0.5 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0076 | 0 | 0.5 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0076 | 0 | 0.5 |
Entamoeba histolytica | aminopeptidase, putative | 0.0076 | 0 | 0.5 |
Onchocerca volvulus | 0.0258 | 1 | 1 | |
Echinococcus granulosus | aminopeptidase N | 0.0258 | 1 | 1 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0076 | 0 | 0.5 |
Echinococcus multilocularis | aminopeptidase N | 0.0258 | 1 | 1 |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.0076 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.5828 | 0.683 |
Loa Loa (eye worm) | hypothetical protein | 0.0232 | 0.8533 | 1 |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.0076 | 0 | 0.5 |
Schistosoma mansoni | cytosol alanyl aminopeptidase (M01 family) | 0.0076 | 0 | 0.5 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0076 | 0 | 0.5 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0076 | 0 | 0.5 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0076 | 0 | 0.5 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0076 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 45 nM | In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay | ChEMBL. | 9171878 |
IC50 (binding) | = 45 nM | In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay | ChEMBL. | 9171878 |
IC50 (binding) | = 17700 nM | In vitro inhibition of endothelin binding to human Endothelin B receptor using [125I]-labeled ET-1 competition assay | ChEMBL. | 9171878 |
IC50 (binding) | = 17700 nM | In vitro inhibition of endothelin binding to human Endothelin B receptor using [125I]-labeled ET-1 competition assay | ChEMBL. | 9171878 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.