Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0039 | 0.2288 | 0.2985 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0014 | 0 | 0.5 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0063 | 0.4407 | 1 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.01 | 0.7665 | 1 |
Brugia malayi | hypothetical protein | 0.0092 | 0.6943 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0039 | 0.2288 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.009 | 0.6774 | 0.8837 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0063 | 0.4407 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.009 | 0.6774 | 0.8837 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.6943 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0039 | 0.2288 | 1 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0014 | 0 | 0.5 |
Plasmodium falciparum | thioredoxin reductase | 0.0039 | 0.2288 | 1 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.009 | 0.6774 | 0.8837 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0014 | 0 | 0.5 |
Brugia malayi | Thioredoxin reductase | 0.0039 | 0.2288 | 0.3295 |
Plasmodium vivax | glutathione reductase, putative | 0.0039 | 0.2288 | 1 |
Schistosoma mansoni | eyes absent homolog | 0.0092 | 0.6943 | 0.6943 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0014 | 0 | 0.5 |
Leishmania major | trypanothione reductase | 0.0039 | 0.2288 | 0.5192 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0063 | 0.4407 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.01 | 0.7665 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.004 | 0.2335 | 0.5298 |
Brugia malayi | glutathione reductase | 0.0039 | 0.2288 | 0.3295 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0063 | 0.4407 | 1 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.009 | 0.6774 | 0.8837 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.009 | 0.6774 | 0.8837 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.01 | 0.7665 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0039 | 0.2288 | 0.5192 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0063 | 0.4407 | 0.4407 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0014 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.009 | 0.6774 | 0.8837 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0063 | 0.4407 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0039 | 0.2288 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0063 | 0.4407 | 1 |
Treponema pallidum | NADH oxidase | 0.0014 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0063 | 0.4407 | 0.575 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0063 | 0.4407 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0039 | 0.2288 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.01 | 0.7665 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0063 | 0.4407 | 0.4407 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.6943 | 1 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0014 | 0 | 0.5 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.004 | 0.2335 | 0.5298 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.