Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0193 | 0.7665 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.0174 | 0.6774 | 0.8837 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0174 | 0.6774 | 0.8837 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0193 | 0.7665 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.2948 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0077 | 0.2335 | 1 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0174 | 0.6774 | 0.8837 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0026 | 0 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 0.1654 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0077 | 0.2335 | 1 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0174 | 0.6774 | 0.8837 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0062 | 0.1654 | 0.1654 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0062 | 0.1654 | 0.7083 |
Plasmodium vivax | glutathione reductase, putative | 0.0076 | 0.2288 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.2948 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0076 | 0.2288 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 0.1654 | 1 |
Treponema pallidum | NADH oxidase | 0.0026 | 0 | 0.5 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0193 | 0.7665 | 1 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0026 | 0 | 0.5 |
Brugia malayi | Thioredoxin reductase | 0.0076 | 0.2288 | 0.7763 |
Leishmania major | trypanothione reductase | 0.0076 | 0.2288 | 1 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0026 | 0 | 0.5 |
Plasmodium falciparum | thioredoxin reductase | 0.0076 | 0.2288 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0193 | 0.7665 | 1 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0026 | 0 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0062 | 0.1654 | 0.1654 |
Trypanosoma brucei | trypanothione reductase | 0.0076 | 0.2288 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0026 | 0 | 0.5 |
Toxoplasma gondii | thioredoxin reductase | 0.0076 | 0.2288 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 0.1654 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0174 | 0.6774 | 0.8837 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0062 | 0.1654 | 0.2158 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0026 | 0 | 0.5 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0076 | 0.2288 | 1 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0076 | 0.2288 | 0.2985 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0174 | 0.6774 | 0.8837 |
Plasmodium falciparum | glutathione reductase | 0.0076 | 0.2288 | 1 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0062 | 0.1654 | 0.7228 |
Schistosoma mansoni | eyes absent homolog | 0.0091 | 0.2948 | 0.2948 |
Brugia malayi | glutathione reductase | 0.0076 | 0.2288 | 0.7763 |
Brugia malayi | hypothetical protein | 0.0091 | 0.2948 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0062 | 0.1654 | 0.7083 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0062 | 0.1654 | 0.7228 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.