Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | glutathione reductase, putative | 0.0082 | 0.2288 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0082 | 0.2288 | 0.7286 |
Trypanosoma brucei | trypanothione reductase | 0.0082 | 0.2288 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0082 | 0.2288 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0083 | 0.2335 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.007 | 0.1787 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.007 | 0.1787 | 1 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.007 | 0.1787 | 0.7652 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.007 | 0.1787 | 0.1787 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0082 | 0.2288 | 1 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0187 | 0.6774 | 0.8837 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0187 | 0.6774 | 0.8837 |
Treponema pallidum | NADH oxidase | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.314 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0082 | 0.2288 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0208 | 0.7665 | 1 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0187 | 0.6774 | 0.8837 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0083 | 0.2335 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0028 | 0 | 0.5 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0028 | 0 | 0.5 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0082 | 0.2288 | 0.2985 |
Brugia malayi | glutathione reductase | 0.0082 | 0.2288 | 0.7286 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0082 | 0.2288 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.007 | 0.1787 | 0.7652 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0187 | 0.6774 | 0.8837 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.007 | 0.1787 | 0.1787 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0208 | 0.7665 | 1 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0028 | 0 | 0.5 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0208 | 0.7665 | 1 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.007 | 0.1787 | 0.2331 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0208 | 0.7665 | 1 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0028 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable reductase | 0.0187 | 0.6774 | 0.8837 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.007 | 0.1787 | 1 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.007 | 0.1787 | 0.7808 |
Toxoplasma gondii | thioredoxin reductase | 0.0082 | 0.2288 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.314 | 1 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0187 | 0.6774 | 0.8837 |
Leishmania major | trypanothione reductase | 0.0082 | 0.2288 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.007 | 0.1787 | 0.7808 |
Schistosoma mansoni | eyes absent homolog | 0.0102 | 0.314 | 0.314 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0028 | 0 | 0.5 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0028 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0102 | 0.314 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.