Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.1195 | 0.1195 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0226 | 0.1195 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0226 | 0.1195 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0226 | 0.1195 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0226 | 0.1195 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0226 | 0.1195 | 1 |
Onchocerca volvulus | 0.0489 | 1 | 1 | |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0226 | 0.1195 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0226 | 0.1195 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0226 | 0.1195 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0489 | 1 | 1 |
Loa Loa (eye worm) | thrombospondin type 1 domain-containing protein | 0.0489 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.1195 | 0.1195 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0226 | 0.1195 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0226 | 0.1195 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.1195 | 0.1195 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0226 | 0.1195 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 0.91 uM | In vitro antiviral activity in Phytohemagglutinin stimulated human PBM cells infected with HIV-1 (strain LAV-1) | ChEMBL. | 2033597 |
MTC (ADMET) | > 1 uM | In vitro toxicity on uninfected Phytohemagglutinin stimulated human PBM cell | ChEMBL. | 2033597 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.