Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | muscleblind-like splicing regulator 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132352 | All targets in OG5_132352 |
Echinococcus granulosus | muscleblind protein | Get druggable targets OG5_132352 | All targets in OG5_132352 |
Echinococcus multilocularis | muscleblind protein | Get druggable targets OG5_132352 | All targets in OG5_132352 |
Brugia malayi | Muscleblind-like protein | Get druggable targets OG5_132352 | All targets in OG5_132352 |
Echinococcus multilocularis | muscleblind protein 1 | Get druggable targets OG5_132352 | All targets in OG5_132352 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132352 | All targets in OG5_132352 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.4248 | 0.3761 |
Leishmania major | macrophage migration inhibitory factor-like protein | 0.0371 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0065 | 0.078 | 0.1191 |
Schistosoma mansoni | tar DNA-binding protein | 0.0257 | 0.655 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0257 | 0.655 | 1 |
Echinococcus granulosus | muscleblind protein | 0.018 | 0.4248 | 0.6485 |
Echinococcus granulosus | geminin | 0.0168 | 0.3887 | 0.5933 |
Brugia malayi | RNA binding protein | 0.0257 | 0.655 | 0.655 |
Plasmodium falciparum | macrophage migration inhibitory factor | 0.0371 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0065 | 0.078 | 0.1191 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0371 | 1 | 0.5 |
Loa Loa (eye worm) | macrophage migration inhibitory factor 2 | 0.0179 | 0.4199 | 0.3708 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 0.3887 | 0.5933 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0065 | 0.078 | 0.1191 |
Toxoplasma gondii | macrophage migration inhibitory factor, putative | 0.0371 | 1 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0207 | 0.5038 | 0.5038 |
Schistosoma mansoni | hypothetical protein | 0.0141 | 0.3067 | 0.4682 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.4248 | 0.3761 |
Schistosoma mansoni | tar DNA-binding protein | 0.0257 | 0.655 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0065 | 0.078 | 0.1191 |
Echinococcus multilocularis | GPCR, family 2 | 0.0065 | 0.078 | 0.1191 |
Schistosoma mansoni | hypothetical protein | 0.0065 | 0.078 | 0.1191 |
Loa Loa (eye worm) | macrophage migration inhibitory factor 2 | 0.0179 | 0.4199 | 0.3708 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0065 | 0.078 | 0.1191 |
Loa Loa (eye worm) | RNA binding protein | 0.0257 | 0.655 | 0.6259 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0065 | 0.078 | 0.078 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.3067 | 0.248 |
Loa Loa (eye worm) | macrophage migration inhibitory factor | 0.0371 | 1 | 1 |
Trichomonas vaginalis | macrophage migration inhibitory factor, mif, putative | 0.0371 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0065 | 0.078 | 0.1191 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 0.3887 | 0.5933 |
Echinococcus multilocularis | muscleblind protein 1 | 0.018 | 0.4248 | 0.6485 |
Plasmodium vivax | macrophage migration inhibitory factor, putative | 0.0371 | 1 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0257 | 0.655 | 0.655 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0207 | 0.5038 | 0.4618 |
Brugia malayi | Muscleblind-like protein | 0.018 | 0.4248 | 0.4248 |
Loa Loa (eye worm) | TAR-binding protein | 0.0257 | 0.655 | 0.6259 |
Schistosoma mansoni | tar DNA-binding protein | 0.0257 | 0.655 | 1 |
Giardia lamblia | Macrophage migration inhibitory factor | 0.0371 | 1 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0257 | 0.655 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0257 | 0.655 | 1 |
Entamoeba histolytica | macrophage migration inhibitory factor-like protein | 0.0371 | 1 | 1 |
Echinococcus multilocularis | geminin | 0.0168 | 0.3887 | 0.5933 |
Leishmania major | macrophage migration inhibitory factor-like protein | 0.0371 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0207 | 0.5038 | 0.4618 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0141 | 0.3067 | 0.3067 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0065 | 0.078 | 0.1191 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0065 | 0.078 | 0.078 |
Brugia malayi | TAR-binding protein | 0.0257 | 0.655 | 0.655 |
Echinococcus multilocularis | muscleblind protein | 0.018 | 0.4248 | 0.6485 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0207 | 0.5038 | 0.5038 |
Echinococcus granulosus | GPCR family 2 | 0.0065 | 0.078 | 0.1191 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0257 | 0.655 | 0.6259 |
Schistosoma mansoni | tar DNA-binding protein | 0.0257 | 0.655 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 2.6169 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (binding) | 14.1254 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.