Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0107 | 0.1774 | 0.1774 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0083 | 0.0405 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.1774 | 0.1664 |
Loa Loa (eye worm) | acetyltransferase | 0.015 | 0.4238 | 0.4659 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.015 | 0.4238 | 0.4238 |
Echinococcus multilocularis | Tolloid protein 1 | 0.0107 | 0.1774 | 0.3571 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0107 | 0.1774 | 0.1664 |
Loa Loa (eye worm) | hypothetical protein | 0.0228 | 0.8631 | 1 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.015 | 0.4238 | 1 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0083 | 0.0405 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0228 | 0.8631 | 0.8631 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.015 | 0.4238 | 0.4659 |
Brugia malayi | Trypsin family protein | 0.0228 | 0.8631 | 1 |
Echinococcus granulosus | Tolloid protein 1 | 0.0107 | 0.1774 | 0.3808 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0146 | 0.3999 | 1 |
Schistosoma mansoni | egf-like domain protein | 0.0083 | 0.0405 | 0.0405 |
Loa Loa (eye worm) | hypothetical protein | 0.0228 | 0.8631 | 1 |
Onchocerca volvulus | 0.0228 | 0.8631 | 1 | |
Onchocerca volvulus | 0.0177 | 0.5724 | 0.6466 | |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.5072 | 0.5673 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.