Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | transfer RNA-Lys | 0.009 | 0.0705 | 0.0705 |
Trichomonas vaginalis | adenylate and guanylate cyclases, putative | 0.0032 | 0 | 0.5 |
Loa Loa (eye worm) | NNMT/PNMT/TEMT family protein | 0.0311 | 0.338 | 0.7308 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0032 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0335 | 0.366 | 0.7485 |
Trichomonas vaginalis | adenylate cyclase, putative | 0.0032 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.4625 | 1 |
Schistosoma mansoni | single-minded | 0.0122 | 0.1086 | 0.1248 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0032 | 0 | 0.5 |
Brugia malayi | hypoxia-induced factor 1 | 0.0376 | 0.4161 | 0.8623 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0122 | 0.1086 | 0.1248 |
Trichomonas vaginalis | guanylate cyclase, putative | 0.0032 | 0 | 0.5 |
Trichomonas vaginalis | adenylate and guanylate cyclases, putative | 0.0032 | 0 | 0.5 |
Echinococcus granulosus | single minded 2 | 0.009 | 0.0705 | 0.1156 |
Onchocerca volvulus | 0.0335 | 0.366 | 1 | |
Entamoeba histolytica | Acid sphingomyelinase-like phosphodiesterase, putative | 0.0174 | 0.172 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0426 | 0.4766 | 0.4766 |
Chlamydia trachomatis | two component regulatory system sensor histidine kinase | 0.0032 | 0 | 0.5 |
Leishmania major | PAS-domain containing phosphoglycerate kinase, putative | 0.0032 | 0 | 0.5 |
Trichomonas vaginalis | adenylate cyclase, type VII, putative | 0.0032 | 0 | 0.5 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0062 | 0.0372 | 0.0372 |
Brugia malayi | bHLH-PAS transcription factor | 0.009 | 0.0705 | 0.0758 |
Loa Loa (eye worm) | hypothetical protein | 0.0408 | 0.4542 | 0.9822 |
Trichomonas vaginalis | soluble guanylate cyclase gcy, putative | 0.0032 | 0 | 0.5 |
Echinococcus multilocularis | jun protein | 0.0426 | 0.4766 | 0.4766 |
Echinococcus multilocularis | geminin | 0.0537 | 0.6099 | 0.6099 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0426 | 0.4766 | 0.7814 |
Schistosoma mansoni | hypothetical protein | 0.0537 | 0.6099 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0346 | 0.3802 | 0.5988 |
Trichomonas vaginalis | guanylate cyclase, putative | 0.0032 | 0 | 0.5 |
Trypanosoma cruzi | PAS-domain containing phosphoglycerate kinase, putative | 0.0032 | 0 | 0.5 |
Mycobacterium ulcerans | putative regulatory protein | 0.009 | 0.0705 | 0.5 |
Leishmania major | protein kinase, putative | 0.0032 | 0 | 0.5 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0376 | 0.4161 | 0.8997 |
Schistosoma mansoni | jun-related protein | 0.0346 | 0.3802 | 0.5988 |
Echinococcus granulosus | jun protein | 0.0426 | 0.4766 | 0.7814 |
Brugia malayi | hypothetical protein | 0.0408 | 0.4542 | 0.9491 |
Leishmania major | protein kinase, putative | 0.0032 | 0 | 0.5 |
Entamoeba histolytica | Acid sphingomyelinase-like phosphodiesterase, putative | 0.0174 | 0.172 | 0.5 |
Trypanosoma cruzi | STE group serine/threonine-protein kinase, putative | 0.0032 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0311 | 0.338 | 0.7308 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0062 | 0.0372 | 0.0803 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0062 | 0.0372 | 0.0372 |
Brugia malayi | bZIP transcription factor family protein | 0.0426 | 0.4766 | 1 |
Trypanosoma cruzi | STE group serine/threonine-protein kinase, putative | 0.0032 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0032 | 0 | 0.5 |
Echinococcus granulosus | geminin | 0.0537 | 0.6099 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 0.172 | 0.3719 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0062 | 0.0372 | 0.0609 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0032 | 0 | 0.5 |
Trypanosoma cruzi | PAS-domain containing phosphoglycerate kinase, putative | 0.0032 | 0 | 0.5 |
Brugia malayi | PAS domain containing protein | 0.0122 | 0.1086 | 0.1626 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0032 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0311 | 0.338 | 0.7308 |
Brugia malayi | NNMT/PNMT/TEMT family protein | 0.0311 | 0.338 | 0.6846 |
Mycobacterium leprae | Possible regulatory protein | 0.0032 | 0 | 0.5 |
Trichomonas vaginalis | adenylate and guanylate cyclases, putative | 0.0032 | 0 | 0.5 |
Onchocerca volvulus | 0.009 | 0.0705 | 0.1925 | |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0062 | 0.0372 | 0.0609 |
Schistosoma mansoni | hypothetical protein | 0.0537 | 0.6099 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.