Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | aldehyde reductase | 0.0044 | 0.257 | 0.257 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0062 | 0.4462 | 0.4462 |
Trypanosoma brucei | prostaglandin f synthase | 0.0062 | 0.4462 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.0062 | 0.4462 | 1 |
Trypanosoma brucei | aldo-keto reductase, putative | 0.0062 | 0.4462 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0062 | 0.4462 | 0.4462 |
Onchocerca volvulus | 0.0062 | 0.4462 | 1 | |
Echinococcus granulosus | aldehyde reductase | 0.0044 | 0.257 | 0.257 |
Giardia lamblia | Aldose reductase | 0.0062 | 0.4462 | 0.5 |
Leishmania major | prostaglandin f synthase, putative | 0.0062 | 0.4462 | 0.5 |
Onchocerca volvulus | 0.0062 | 0.4462 | 1 | |
Entamoeba histolytica | aldose reductase, putative | 0.0062 | 0.4462 | 0.5 |
Schistosoma mansoni | lipoxygenase | 0.008 | 0.6368 | 0.6368 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0062 | 0.4462 | 0.4462 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0062 | 0.4462 | 0.4462 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0062 | 0.4462 | 0.5 |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.0062 | 0.4462 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.0062 | 0.4462 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0062 | 0.4462 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0115 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0062 | 0.4462 | 0.5 |
Schistosoma mansoni | aldo-keto reductase | 0.0062 | 0.4462 | 0.4462 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0062 | 0.4462 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.0062 | 0.4462 | 1 |
Onchocerca volvulus | 0.0062 | 0.4462 | 1 | |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0062 | 0.4462 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0062 | 0.4462 | 0.4462 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.4462 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0062 | 0.4462 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0062 | 0.4462 | 0.4462 |
Echinococcus granulosus | hypothetical protein | 0.0062 | 0.4462 | 0.4462 |
Onchocerca volvulus | 0.0062 | 0.4462 | 1 | |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0062 | 0.4462 | 0.4462 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0062 | 0.4462 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0062 | 0.4462 | 0.5 |
Schistosoma mansoni | aldo-keto reductase | 0.0062 | 0.4462 | 0.4462 |
Echinococcus multilocularis | aldo keto reductase | 0.0062 | 0.4462 | 0.4462 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0062 | 0.4462 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0062 | 0.4462 | 0.5 |
Schistosoma mansoni | pol-related | 0.0062 | 0.4462 | 0.4462 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0062 | 0.4462 | 0.4462 |
Mycobacterium ulcerans | oxidoreductase | 0.0062 | 0.4462 | 0.5 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0062 | 0.4462 | 0.5 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0062 | 0.4462 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0062 | 0.4462 | 0.4462 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0062 | 0.4462 | 0.4462 |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.0062 | 0.4462 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0062 | 0.4462 | 0.5 |
Toxoplasma gondii | aldose reductase, putative | 0.0062 | 0.4462 | 0.5 |
Entamoeba histolytica | aldose reductase, putative | 0.0062 | 0.4462 | 0.5 |
Echinococcus multilocularis | aldo keto reductase | 0.0062 | 0.4462 | 0.4462 |
Loa Loa (eye worm) | oxidoreductase | 0.0062 | 0.4462 | 1 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0115 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0062 | 0.4462 | 0.4462 |
Leishmania major | aldo-keto reductase-like protein | 0.0062 | 0.4462 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0062 | 0.4462 | 0.5 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0062 | 0.4462 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0062 | 0.4462 | 0.4462 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0062 | 0.4462 | 0.4462 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0062 | 0.4462 | 0.4462 |
Echinococcus multilocularis | aldo keto reductase | 0.0062 | 0.4462 | 0.4462 |
Entamoeba histolytica | aldose reductase, putative | 0.0062 | 0.4462 | 0.5 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0062 | 0.4462 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0062 | 0.4462 | 0.4462 |
Echinococcus granulosus | aldo keto reductase | 0.0062 | 0.4462 | 0.4462 |
Loa Loa (eye worm) | oxidoreductase | 0.0062 | 0.4462 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0062 | 0.4462 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0062 | 0.4462 | 0.4462 |
Leishmania major | aldehyde reductase, putative,oxidoreductase, putative | 0.0062 | 0.4462 | 0.5 |
Echinococcus multilocularis | aldo keto reductase | 0.0062 | 0.4462 | 0.4462 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0062 | 0.4462 | 1 |
Trypanosoma cruzi | aldo-keto reductase | 0.0062 | 0.4462 | 0.5 |
Echinococcus granulosus | aldo keto reductase | 0.0062 | 0.4462 | 0.4462 |
Giardia lamblia | Aldose reductase | 0.0062 | 0.4462 | 0.5 |
Onchocerca volvulus | 0.0062 | 0.4462 | 1 | |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0062 | 0.4462 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0062 | 0.4462 | 0.4462 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0062 | 0.4462 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0062 | 0.4462 | 0.4462 |
Leishmania major | prostaglandin f2-alpha synthase/D-arabinose dehydrogenase | 0.0062 | 0.4462 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0062 | 0.4462 | 0.4462 |
Echinococcus granulosus | aldo keto reductase | 0.0062 | 0.4462 | 0.4462 |
Onchocerca volvulus | 0.0062 | 0.4462 | 1 | |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0062 | 0.4462 | 0.4462 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0062 | 0.4462 | 0.5 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0062 | 0.4462 | 0.5 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0062 | 0.4462 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 152 uM | Binding affinity against Sodium/glucose cotransporter of isolated renal brush border membranes. | ChEMBL. | 10794686 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.