Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0083 | 0.3512 | 0.5 | |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.1177 | 0.1114 |
Toxoplasma gondii | thioredoxin reductase | 0.0047 | 0.0997 | 0.0746 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0047 | 0.0997 | 0.224 |
Loa Loa (eye worm) | macrophage migration inhibitory factor 2 | 0.0075 | 0.2936 | 0.2886 |
Brugia malayi | Inositol-1 | 0.0037 | 0.0271 | 0.0202 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0037 | 0.0271 | 0.5 |
Trichomonas vaginalis | macrophage migration inhibitory factor, mif, putative | 0.0175 | 1 | 1 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0108 | 0.5245 | 0.8614 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.012 | 0.6089 | 1 |
Brugia malayi | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 0.0083 | 0.3512 | 0.3465 |
Plasmodium vivax | macrophage migration inhibitory factor, putative | 0.0175 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.3512 | 0.3465 |
Loa Loa (eye worm) | glutathione reductase | 0.0047 | 0.0997 | 0.0933 |
Mycobacterium tuberculosis | Probable reductase | 0.0108 | 0.5245 | 0.8614 |
Giardia lamblia | Macrophage migration inhibitory factor | 0.0175 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0108 | 0.5245 | 0.8614 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.1177 | 0.1114 |
Brugia malayi | Thioredoxin reductase | 0.0047 | 0.0997 | 0.0933 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0047 | 0.0997 | 0.224 |
Schistosoma mansoni | inositol monophosphatase | 0.0037 | 0.0271 | 0.0245 |
Toxoplasma gondii | macrophage migration inhibitory factor, putative | 0.0175 | 1 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0047 | 0.0997 | 1 |
Leishmania major | macrophage migration inhibitory factor-like protein | 0.0175 | 1 | 1 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.0083 | 0.3512 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.1177 | 0.1114 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.1177 | 0.1114 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.012 | 0.6089 | 1 |
Brugia malayi | glutathione reductase | 0.0047 | 0.0997 | 0.0933 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.012 | 0.6089 | 1 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0037 | 0.0271 | 0.5 |
Schistosoma mansoni | inositol monophosphatase | 0.0037 | 0.0271 | 0.0245 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0108 | 0.5245 | 0.8614 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.012 | 0.6089 | 1 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0047 | 0.0997 | 0.1638 |
Plasmodium falciparum | macrophage migration inhibitory factor | 0.0175 | 1 | 1 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0108 | 0.5245 | 0.8614 |
Loa Loa (eye worm) | macrophage migration inhibitory factor 2 | 0.0075 | 0.2936 | 0.2886 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0108 | 0.5245 | 0.8614 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0175 | 1 | 1 |
Leishmania major | trypanothione reductase | 0.0047 | 0.0997 | 0.0746 |
Entamoeba histolytica | macrophage migration inhibitory factor-like protein | 0.0175 | 1 | 1 |
Loa Loa (eye worm) | inositol-1 | 0.0037 | 0.0271 | 0.0202 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0108 | 0.5245 | 0.8614 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0083 | 0.3512 | 0.4204 |
Trypanosoma brucei | trypanothione reductase | 0.0047 | 0.0997 | 1 |
Loa Loa (eye worm) | macrophage migration inhibitory factor | 0.0175 | 1 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0047 | 0.0997 | 0.0933 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0083 | 0.3512 | 1 |
Leishmania major | macrophage migration inhibitory factor-like protein | 0.0175 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.