Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0758 | 0.3717 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0758 | 0.3717 | 0.3717 |
Echinococcus granulosus | adenylate cyclase type IX | 0.0748 | 0.3571 | 0.5 |
Echinococcus multilocularis | adenylate cyclase type IX | 0.0748 | 0.3571 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.107 | 0.8566 | 0.8566 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0758 | 0.3717 | 0.3717 |
Schistosoma mansoni | hypothetical protein | 0.0518 | 0 | 0.5 |
Onchocerca volvulus | Adenylate cyclase type 3 homolog | 0.1096 | 0.8964 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0758 | 0.3717 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.1 uM | Displacement of 3[H]Flunitrazepam from GABA-A central benzodiazepine receptor of bovine brain membranes | ChEMBL. | 2821257 |
Inhibition (binding) | 0 % | Displacement of 3[H]Flunitrazepam from GABA-A central benzodiazepine receptor of bovine brain membranes (no data) | ChEMBL. | 2821257 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.