Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0018 | 0.0013 | 0.0047 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0079 | 0.0212 | 0.2031 |
Onchocerca volvulus | 0.0141 | 0.0416 | 0.0292 | |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0018 | 0.0013 | 0.0305 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0018 | 0.0013 | 0.0047 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0079 | 0.0212 | 0.2031 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0013 | 0.0302 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0079 | 0.0212 | 0.2031 |
Schistosoma mansoni | neuropeptide receptor | 0.0317 | 0.0993 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0013 | 0.0001 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0018 | 0.0013 | 0.0001 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0013 | 0.0001 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0018 | 0.0013 | 0.0047 |
Leishmania major | diacylglycerol acyltransferase, putative | 0.0054 | 0.0128 | 0.0476 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.0835 | 0.2697 | 1 |
Brugia malayi | diacylglycerol acyltransferase family protein | 0.0054 | 0.0128 | 0.0177 |
Trypanosoma cruzi | diacylglycerol acyltransferase, putative | 0.0054 | 0.0128 | 0.0476 |
Loa Loa (eye worm) | pax transcription factor protein 2 | 0.0141 | 0.0416 | 1 |
Brugia malayi | Isocitrate dehydrogenase | 0.0018 | 0.0013 | 0.0017 |
Schistosoma mansoni | diacylglycerol O-acyltransferase 1 | 0.0054 | 0.0128 | 0.1182 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0079 | 0.0212 | 0.2031 |
Echinococcus granulosus | neuropeptide receptor | 0.0317 | 0.0993 | 1 |
Trypanosoma cruzi | diacylglycerol acyltransferase, putative | 0.0054 | 0.0128 | 0.0476 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0058 | 0.0143 | 0.3426 |
Loa Loa (eye worm) | diacylglycerol acyltransferase | 0.0054 | 0.0128 | 0.3085 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0018 | 0.0013 | 0.0047 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0018 | 0.0013 | 0.0047 |
Echinococcus multilocularis | neuropeptide receptor | 0.0317 | 0.0993 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0082 | 0.198 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.004 | 0.0082 | 0.0114 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0018 | 0.0013 | 0.0001 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0018 | 0.0013 | 0.0302 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0018 | 0.0013 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0079 | 0.0212 | 0.2031 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0018 | 0.0013 | 0.0047 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0013 | 0.0001 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0018 | 0.0013 | 0.0047 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0079 | 0.0212 | 0.0292 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0018 | 0.0013 | 0.0001 |
Toxoplasma gondii | dgat2l1-prov protein | 0.0054 | 0.0128 | 0.0476 |
Giardia lamblia | Telomerase catalytic subunit | 0.0835 | 0.2697 | 0.5 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0018 | 0.0013 | 0.0017 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0143 | 0.3426 |
Brugia malayi | isocitrate dehydrogenase | 0.0018 | 0.0013 | 0.0017 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0058 | 0.0143 | 0.0197 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.0835 | 0.2697 | 1 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0835 | 0.2697 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0079 | 0.0212 | 0.5083 |
Brugia malayi | Telomerase reverse transcriptase | 0.2223 | 0.7256 | 1 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0018 | 0.0013 | 0.0047 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0079 | 0.0212 | 0.2031 |
Trypanosoma brucei | diacylglycerol acyltransferase, putative | 0.0054 | 0.0128 | 0.0476 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0018 | 0.0013 | 0.0047 |
Brugia malayi | Pax transcription factor protein 2 | 0.0141 | 0.0416 | 0.0574 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0079 | 0.0212 | 0.2031 |
Echinococcus multilocularis | G protein coupled receptor 139 | 0.0317 | 0.0993 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0018 | 0.0013 | 0.0017 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0013 | 0.0001 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0058 | 0.0143 | 0.0197 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0082 | 0.0713 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.0835 | 0.2697 | 1 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.0835 | 0.2697 | 1 |
Leishmania major | telomerase reverse transcriptase, putative | 0.0835 | 0.2697 | 1 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0835 | 0.2697 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.