Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | histone deacetylase 2 | 0.0112 | 0.0938 | 0.2378 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0344 | 0.3944 | 1 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0112 | 0.0938 | 0.2378 |
Schistosoma mansoni | ets-related | 0.0228 | 0.2434 | 0.6171 |
Echinococcus granulosus | histone deacetylase 6 | 0.0112 | 0.0938 | 0.2134 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0112 | 0.0938 | 0.0938 |
Echinococcus multilocularis | histone deacetylase 7 | 0.0112 | 0.0938 | 0.0938 |
Trypanosoma brucei | histone deacetylase, putative | 0.0112 | 0.0938 | 0.2378 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0112 | 0.0936 | 0.0936 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.0344 | 0.3944 | 0.8974 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0428 | 0.1086 |
Schistosoma mansoni | family M1 non-peptidase homologue (M01 family) | 0.0072 | 0.0428 | 0.1086 |
Giardia lamblia | Histone deacetylase | 0.0344 | 0.3944 | 0.5 |
Onchocerca volvulus | Histone deacetylase 10 homolog | 0.0112 | 0.0938 | 0.2134 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0112 | 0.0938 | 0.2378 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0344 | 0.3944 | 1 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0112 | 0.0936 | 0.2372 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0344 | 0.3944 | 1 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0112 | 0.0936 | 0.2129 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0112 | 0.0938 | 0.0938 |
Brugia malayi | Ets-domain containing protein | 0.0075 | 0.0461 | 0.105 |
Brugia malayi | histone deacetylase 3 (HD3) | 0.0344 | 0.3944 | 0.8974 |
Brugia malayi | hypothetical protein | 0.0112 | 0.0936 | 0.2129 |
Brugia malayi | Fli-1 protein | 0.0228 | 0.2434 | 0.5538 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0344 | 0.3944 | 1 |
Schistosoma mansoni | histone deacetylase | 0.0344 | 0.3944 | 1 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0112 | 0.0936 | 0.2372 |
Echinococcus multilocularis | Peptidase M1, membrane alanine aminopeptidase, N terminal | 0.0112 | 0.0936 | 0.0936 |
Echinococcus multilocularis | histone deacetylase | 0.0112 | 0.0938 | 0.0938 |
Loa Loa (eye worm) | hypothetical protein | 0.0268 | 0.2952 | 0.7485 |
Echinococcus multilocularis | aminopeptidase N | 0.0379 | 0.4395 | 0.4395 |
Toxoplasma gondii | histone deacetylase HDAC4 | 0.0112 | 0.0938 | 0.2378 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0307 | 0.346 | 0.8771 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0072 | 0.0428 | 0.0428 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.0938 | 0.2378 |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.0112 | 0.0936 | 0.2372 |
Brugia malayi | Ets-domain containing protein | 0.0075 | 0.0461 | 0.105 |
Leishmania major | histone deacetylase, putative | 0.0344 | 0.3944 | 1 |
Echinococcus granulosus | GA binding protein alpha chain | 0.0075 | 0.0461 | 0.105 |
Plasmodium vivax | histone deacetylase, putative | 0.0112 | 0.0938 | 0.2378 |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.0112 | 0.0936 | 1 |
Brugia malayi | Histone deacetylase family protein | 0.0112 | 0.0938 | 0.2134 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0112 | 0.0936 | 0.2129 |
Trypanosoma brucei | histone deacetylase 3 | 0.0112 | 0.0938 | 0.2378 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0112 | 0.0936 | 0.0936 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0112 | 0.0938 | 0.2378 |
Schistosoma mansoni | histone deacetylase | 0.0344 | 0.3944 | 1 |
Schistosoma mansoni | cytosol alanyl aminopeptidase (M01 family) | 0.0112 | 0.0936 | 0.2372 |
Brugia malayi | Histone deacetylase 1 | 0.0344 | 0.3944 | 0.8974 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0428 | 0.1086 |
Plasmodium vivax | histone deacetylase, putative | 0.0112 | 0.0938 | 0.2378 |
Trypanosoma brucei | histone deacetylase 1 | 0.0344 | 0.3944 | 1 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.0112 | 0.0938 | 0.2378 |
Brugia malayi | Histone deacetylase family protein | 0.0112 | 0.0938 | 0.2134 |
Echinococcus multilocularis | histone deacetylase 8 | 0.0112 | 0.0938 | 0.0938 |
Plasmodium falciparum | histone deacetylase 1 | 0.0344 | 0.3944 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0344 | 0.3944 | 1 |
Trypanosoma cruzi | metallo-peptidase, Clan MA(E) Family M1 | 0.0072 | 0.0428 | 0.1086 |
Toxoplasma gondii | histone deacetylase HDAC1 | 0.0112 | 0.0938 | 0.2378 |
Leishmania major | histone deacetylase, putative | 0.0112 | 0.0938 | 0.2378 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.0112 | 0.0936 | 0.2372 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0112 | 0.0936 | 0.2129 |
Loa Loa (eye worm) | D-ets-4 DNA binding domain-containing protein | 0.0075 | 0.0461 | 0.117 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0112 | 0.0938 | 0.2378 |
Echinococcus granulosus | aminopeptidase N | 0.0379 | 0.4395 | 1 |
Loa Loa (eye worm) | histone deacetylase 11 | 0.0112 | 0.0938 | 0.2378 |
Brugia malayi | Peptidase family M1 containing protein | 0.0379 | 0.4395 | 1 |
Plasmodium vivax | histone deacetylase 1, putative | 0.0344 | 0.3944 | 1 |
Loa Loa (eye worm) | histone deacetylase | 0.0112 | 0.0938 | 0.2378 |
Echinococcus multilocularis | histone deacetylase 1 | 0.0344 | 0.3944 | 0.3944 |
Plasmodium vivax | histone deacetylase 2, putative | 0.0112 | 0.0938 | 0.2378 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0344 | 0.3944 | 1 |
Echinococcus granulosus | histone deacetylase 3 | 0.0344 | 0.3944 | 0.8974 |
Toxoplasma gondii | histone deacetylase HDAC3 | 0.0344 | 0.3944 | 1 |
Echinococcus granulosus | histone deacetylase | 0.0112 | 0.0938 | 0.2134 |
Echinococcus granulosus | histone deacetylase 6 | 0.0112 | 0.0938 | 0.2134 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0112 | 0.0936 | 0.0936 |
Schistosoma mansoni | gabp alpha | 0.0075 | 0.0461 | 0.117 |
Loa Loa (eye worm) | hypothetical protein | 0.034 | 0.3888 | 0.9857 |
Onchocerca volvulus | 0.0112 | 0.0936 | 0.2129 | |
Echinococcus granulosus | histone deacetylase 6 | 0.0112 | 0.0938 | 0.2134 |
Leishmania major | histone deacetylase, putative | 0.0112 | 0.0938 | 0.2378 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0344 | 0.3944 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0344 | 0.3944 | 1 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0112 | 0.0936 | 0.0936 |
Plasmodium falciparum | histone deacetylase 2 | 0.0112 | 0.0938 | 0.2378 |
Echinococcus granulosus | histone deacetylase 7 | 0.0112 | 0.0938 | 0.2134 |
Brugia malayi | histone deacetylase 11 | 0.0112 | 0.0938 | 0.2134 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0112 | 0.0936 | 0.2129 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0344 | 0.3944 | 1 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0112 | 0.0936 | 0.2372 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0344 | 0.3944 | 1 |
Onchocerca volvulus | 0.0379 | 0.4395 | 1 | |
Trypanosoma brucei | histone deacetylase 4 | 0.0112 | 0.0938 | 0.2378 |
Leishmania major | histone deacetylase, putative | 0.0344 | 0.3944 | 1 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0112 | 0.0938 | 0.0938 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0112 | 0.0936 | 0.2372 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0112 | 0.0938 | 0.2378 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0112 | 0.0936 | 0.2372 |
Loa Loa (eye worm) | fli-1 protein | 0.0228 | 0.2434 | 0.6171 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0344 | 0.3944 | 1 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0112 | 0.0936 | 0.2372 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0112 | 0.0938 | 0.2378 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0112 | 0.0938 | 0.2378 |
Echinococcus granulosus | histone deacetylase 8 | 0.0112 | 0.0938 | 0.2134 |
Brugia malayi | Peptidase family M1 containing protein | 0.0112 | 0.0936 | 0.2129 |
Entamoeba histolytica | histone deacetylase, putative | 0.0344 | 0.3944 | 1 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.0344 | 0.3944 | 1 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.0344 | 0.3944 | 1 |
Loa Loa (eye worm) | aminopeptidase N | 0.0112 | 0.0936 | 0.2372 |
Toxoplasma gondii | histone deacetylase HDAC5 | 0.0112 | 0.0938 | 0.2378 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0344 | 0.3944 | 1 |
Schistosoma mansoni | histone deacetylase 1 2 3 | 0.0112 | 0.0938 | 0.2378 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0344 | 0.3944 | 1 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0112 | 0.0936 | 0.2372 |
Echinococcus granulosus | histone deacetylase 1 | 0.0344 | 0.3944 | 0.8974 |
Plasmodium falciparum | histone deacetylase, putative | 0.0112 | 0.0938 | 0.2378 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0321 | 0.0814 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0112 | 0.0936 | 0.2372 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0112 | 0.0936 | 0.0936 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0112 | 0.0938 | 0.2378 |
Echinococcus multilocularis | GA binding protein alpha chain | 0.0075 | 0.0461 | 0.0461 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0112 | 0.0936 | 0.2372 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0112 | 0.0938 | 0.2378 |
Echinococcus multilocularis | histone deacetylase 3 | 0.0344 | 0.3944 | 0.3944 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.