Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | uM | Inhibitory concentration for peptidolytic activity against herpes simplex type-1 (HSV-1) protease at 10 uM; Not determined | ChEMBL. | No reference |
IC50 (binding) | 0 uM | Inhibitory concentration for peptidolytic activity against herpes simplex type-1 (HSV-1) protease at 10 uM; Not determined | ChEMBL. | No reference |
Inhibition (functional) | = 15 % | Percent inhibition for peptidolytic activity against cytomegalovirus(CMV) protease at 10 uM. | ChEMBL. | No reference |
Inhibition (functional) | = 32 % | Percent inhibition for peptidolytic activity against herpes simplex type-2(HSV-2) protease at 10 uM. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.