Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | pyruvate kinase | 0.0065 | 0.0545 | 0.5 |
Echinococcus granulosus | pyruvate kinase | 0.0065 | 0.0545 | 1 |
Chlamydia trachomatis | pyruvate kinase | 0.0065 | 0.0545 | 0.5 |
Schistosoma mansoni | pyruvate kinase | 0.0065 | 0.0545 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 0.0443 | 0.0443 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 0.0443 | 0.0443 |
Trypanosoma brucei | pyruvate kinase 1, putative | 0.0065 | 0.0545 | 0.5 |
Onchocerca volvulus | Phospholipase A2 homolog | 0.0409 | 1 | 1 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0065 | 0.0545 | 0.5 |
Echinococcus granulosus | pyruvate kinase | 0.0065 | 0.0545 | 1 |
Giardia lamblia | Pyruvate kinase | 0.0065 | 0.0545 | 0.5 |
Echinococcus multilocularis | pyruvate kinase | 0.0065 | 0.0545 | 1 |
Loa Loa (eye worm) | pyruvate kinase | 0.0065 | 0.0545 | 0.0545 |
Trypanosoma brucei | pyruvate kinase 1 | 0.0065 | 0.0545 | 0.5 |
Leishmania major | pyruvate kinase | 0.0065 | 0.0545 | 0.5 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0065 | 0.0545 | 0.5 |
Brugia malayi | Pyruvate kinase, M2 isozyme | 0.0065 | 0.0545 | 0.0107 |
Echinococcus multilocularis | tar DNA binding protein | 0.0062 | 0.0443 | 0.7311 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0065 | 0.0545 | 0.5 |
Plasmodium vivax | pyruvate kinase, putative | 0.0065 | 0.0545 | 0.5 |
Loa Loa (eye worm) | pyruvate kinase | 0.0065 | 0.0545 | 0.0545 |
Echinococcus multilocularis | pyruvate kinase | 0.0065 | 0.0545 | 1 |
Entamoeba histolytica | pyruvate kinase, putative | 0.0046 | 0 | 0.5 |
Onchocerca volvulus | Phospholipase A2 homolog | 0.0409 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0409 | 1 | 1 |
Loa Loa (eye worm) | pyruvate kinase | 0.0065 | 0.0545 | 0.0545 |
Leishmania major | pyruvate kinase | 0.0065 | 0.0545 | 0.5 |
Mycobacterium tuberculosis | Probable pyruvate kinase PykA | 0.0065 | 0.0545 | 0.5 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.0065 | 0.0545 | 0.5 |
Schistosoma mansoni | pyruvate kinase | 0.0065 | 0.0545 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0409 | 1 | 1 |
Brugia malayi | Pyruvate kinase, muscle isozyme | 0.0065 | 0.0545 | 0.0107 |
Plasmodium falciparum | pyruvate kinase | 0.0065 | 0.0545 | 0.5 |
Mycobacterium leprae | Probable pyruvate kinase PykA | 0.0065 | 0.0545 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.0545 | 0.0545 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0065 | 0.0545 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 0.0443 | 0.0443 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.