Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | kinesin-like protein KLP2 | 0.0427 | 0.1284 | 1 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.001 | 0.0015 | 0.0079 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0007 | 0.0004 | 0.0005 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0034 | 0.0085 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0015 | 0.0079 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0036 | 0.0093 | 0.0088 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0039 | 0.0103 | 0.0118 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0007 | 0.0004 | 0.0005 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.001 | 0.0015 | 0.001 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0007 | 0.0004 | 0.0005 |
Brugia malayi | Kinesin motor domain containing protein | 0.0427 | 0.1284 | 1 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0007 | 0.0004 | 0.0005 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0034 | 0.0085 | 1 |
Entamoeba histolytica | kinesin, putative | 0.0427 | 0.1284 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0078 | 0.0576 |
Schistosoma mansoni | voltage-gated potassium channel | 0.001 | 0.0015 | 0.0017 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0039 | 0.0103 | 0.0118 |
Echinococcus multilocularis | kinesin family 1 | 0.329 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0007 | 0.0004 | 0.0005 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.001 | 0.0015 | 0.001 |
Echinococcus multilocularis | voltage gated potassium channel | 0.001 | 0.0015 | 0.001 |
Echinococcus granulosus | voltage gated potassium channel | 0.001 | 0.0015 | 0.001 |
Schistosoma mansoni | voltage-gated potassium channel | 0.001 | 0.0015 | 0.0017 |
Plasmodium falciparum | kinesin-5 | 0.0427 | 0.1284 | 0.5 |
Giardia lamblia | Kinesin-5 | 0.0427 | 0.1284 | 0.5 |
Schistosoma mansoni | kinesin eg-5 | 0.0427 | 0.1284 | 0.1476 |
Schistosoma mansoni | hypothetical protein | 0.2863 | 0.8699 | 1 |
Plasmodium vivax | kinesin-5 | 0.0427 | 0.1284 | 0.5 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0036 | 0.0093 | 0.0088 |
Toxoplasma gondii | kinesin motor domain-containing protein | 0.0427 | 0.1284 | 0.5 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0036 | 0.0093 | 0.069 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0007 | 0.0004 | 0.0005 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0036 | 0.0093 | 0.069 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 6.6 uM | In vitro antiproliferative activity of the compound was measured on human leukemia K562 cells | ChEMBL. | No reference |
IC50 (functional) | = 6.6 uM | In vitro antiproliferative activity of the compound was measured on human leukemia K562 cells | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.