TDR Targets

Basic information

Technical information

TDR Targets ID: 697471
Name: N-[2-furan-2-yl-2-[4-(4-methoxyphenyl)piperaz in-1-yl]ethyl]-4-(trifluoromethyl)benzamide
MW: 473.487 | Formula: C25H26F3N3O3
H donors: 1 H acceptors: 1 LogP: 4.31 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)N1CCN(CC1)C(c1ccco1)CNC(=O)c1ccc(cc1)C(F)(F)F
InChi: 1S/C25H26F3N3O3/c1-33-21-10-8-20(9-11-21)30-12-14-31(15-13-30)22(23-3-2-16-34-23)17-29-24(32)18-4-6-19(7-5-18)25(26,27)28/h2-11,16,22H,12-15,17H2,1H3,(H,29,32)
InChiKey: QKCRYUQCMUUVNC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[2-(2-furyl)-2-[4-(4-methoxyphenyl)piperazin-1-yl]ethyl]-4-(trifluoromethyl)benzamide
N-[2-(2-furyl)-2-[4-(4-methoxyphenyl)-1-piperazinyl]ethyl]-4-(trifluoromethyl)benzamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0079	0.1739	0.6635
Schistosoma mansoni	hypothetical protein	0.0032	0.0248	0.0075
Loa Loa (eye worm)	hypothetical protein	0.005	0.0825	0.0732
Echinococcus granulosus	snurportin 1	0.0314	0.9073	0.9056
Schistosoma mansoni	6-phosphofructokinase	0.0106	0.2564	0.2433
Trypanosoma cruzi	PAB1-binding protein , putative	0.0076	0.1626	0.6342
Loa Loa (eye worm)	6-phosphofructokinase	0.0106	0.2564	0.2686
Schistosoma mansoni	thyroid hormone receptor	0.0143	0.3724	0.3613
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.01	0.2395	0.2496
Plasmodium vivax	ataxin-2 like protein, putative	0.0076	0.1626	0.931
Schistosoma mansoni	hypothetical protein	0.0069	0.1401	0.1249
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0034	0.0318	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1739	0.1758
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0032	0.0248	0.0075
Echinococcus multilocularis	GPCR, family 2	0.0032	0.0248	0.0075
Entamoeba histolytica	phosphofructokinase, putative	0.0106	0.2564	1
Schistosoma mansoni	hypothetical protein	0.0034	0.0318	0.0147
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0132	0.3392	0.3275
Toxoplasma gondii	6-phosphofructokinase	0.0029	0.0148	0.0235
Onchocerca volvulus		0.005	0.0825	0.5
Trichomonas vaginalis	6-phosphofructokinase, putative	0.0029	0.0148	0.0579
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0079	0.1739	1
Brugia malayi	6-phosphofructokinase	0.0106	0.2564	1
Echinococcus multilocularis	geminin	0.0343	1	1
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0314	0.9073	1
Schistosoma mansoni	hypothetical protein	0.0032	0.0248	0.0075
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0079	0.1739	0.1592
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0148	0.0579
Echinococcus multilocularis	tumor protein p63	0.0343	0.9988	0.9988
Loa Loa (eye worm)	hypothetical protein	0.01	0.2395	0.2496
Schistosoma mansoni	6-phosphofructokinase	0.0106	0.2564	0.2433
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0148	0.0579
Echinococcus granulosus	GPCR family 2	0.0032	0.0248	0.0075
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0106	0.2564	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.01	0.2395	0.9292
Trichomonas vaginalis	phosphofructokinase, putative	0.0106	0.2564	1
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0148	0.0579
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0079	0.1739	1
Giardia lamblia	Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit	0.0029	0.0148	0.5
Schistosoma mansoni	peptidase Clp (S14 family)	0.0079	0.1739	0.1592
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0148	0.0579
Schistosoma mansoni	thyroid hormone receptor	0.0143	0.3724	0.3613
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	0.0106	0.2564	1
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0032	0.0248	0.0075
Toxoplasma gondii	phosphofructokinase PFKII	0.0029	0.0148	0.0235
Trypanosoma cruzi	PAB1-binding protein , putative	0.0076	0.1626	0.6342
Brugia malayi	RNA, U transporter 1	0.0084	0.187	0.7094
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0052	0.0883	0.3148
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0079	0.1739	1
Entamoeba histolytica	phosphofructokinase, putative	0.0106	0.2564	1
Loa Loa (eye worm)	6-phosphofructokinase	0.0106	0.2564	0.2686
Schistosoma mansoni	hypothetical protein	0.0343	1	1
Schistosoma mansoni	cellular tumor antigen P53	0.005	0.0825	0.0663
Brugia malayi	6-phosphofructokinase	0.0106	0.2564	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.0076	0.1626	0.931
Plasmodium vivax	importin-beta 2, putative	0.0029	0.0174	0.0392
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0148	0.0579
Toxoplasma gondii	LsmAD domain-containing protein	0.0076	0.1626	0.931
Brugia malayi	phosphofructokinase	0.0106	0.2564	1
Brugia malayi	Probable ClpP-like protease	0.0079	0.1739	0.6546
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0132	0.3392	0.3275
Plasmodium vivax	6-phosphofructokinase, putative	0.0029	0.0148	0.0235
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0032	0.0248	0.0083
Echinococcus granulosus	6 phosphofructokinase	0.0106	0.2564	0.2433
Brugia malayi	hypothetical protein	0.0076	0.1626	0.6076
Plasmodium falciparum	ataxin-2 like protein, putative	0.0076	0.1626	0.931
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0143	0.3724	0.3613
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0079	0.1739	1
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0079	0.1739	0.6635
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0029	0.0148	0.0235
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0029	0.0148	0.0156
Loa Loa (eye worm)	hypothetical protein	0.0076	0.1626	0.1632
Echinococcus multilocularis	6 phosphofructokinase	0.0106	0.2564	0.2433
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	0.0106	0.2564	1
Schistosoma mansoni	hypothetical protein	0.0343	1	1
Trichomonas vaginalis	phosphofructokinase, putative	0.0106	0.2564	1
Toxoplasma gondii	HEAT repeat-containing protein	0.0029	0.0174	0.0392
Schistosoma mansoni	hypothetical protein	0.0132	0.3392	0.3275
Plasmodium vivax	6-phosphofructokinase, putative	0.0029	0.0148	0.0235
Plasmodium falciparum	importin beta, putative	0.0029	0.0174	0.0392
Trichomonas vaginalis	phosphofructokinase, putative	0.0106	0.2564	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0248	0.0083
Mycobacterium ulcerans	6-phosphofructokinase	0.0106	0.2564	1
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0029	0.0148	0.0235
Mycobacterium tuberculosis	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)	0.0106	0.2564	1
Echinococcus granulosus	tumor protein p63	0.0343	0.9988	0.9988
Brugia malayi	latrophilin 2 splice variant baaae	0.0069	0.1401	0.5134
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0079	0.1739	1
Schistosoma mansoni	hypothetical protein	0.0032	0.0248	0.0075
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0079	0.1739	1
Loa Loa (eye worm)	phosphofructokinase	0.0106	0.2564	0.2686
Echinococcus granulosus	peptidase Clp S14 family	0.0052	0.0883	0.0721
Loa Loa (eye worm)	hypothetical protein	0.0069	0.1401	0.1379
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.01	0.2395	0.9292
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0052	0.0883	0.0721
Schistosoma mansoni	hypothetical protein	0.0032	0.0248	0.0075
Trypanosoma brucei	PAB1-binding protein , putative	0.0076	0.1626	0.6076
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0079	0.1739	0.1592
Echinococcus multilocularis	snurportin 1	0.0314	0.9073	0.9056
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0079	0.1739	0.5
Trichomonas vaginalis	phosphofructokinase, putative	0.0106	0.2564	1
Toxoplasma gondii	phosphofructokinase domain-containing protein	0.0029	0.0148	0.0235
Mycobacterium leprae	PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE)	0.0106	0.2564	1
Schistosoma mansoni	hypothetical protein	0.0314	0.9073	0.9056
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0032	0.0248	0.0075
Leishmania major	hypothetical protein, conserved	0.0076	0.1626	0.6342
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0148	0.0579
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0032	0.0248	0.031
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0032	0.0248	0.0075
Entamoeba histolytica	pyrophosphate-dependent phosphofructokinase	0.0029	0.0148	0.0579
Entamoeba histolytica	phosphofructokinase, putative	0.0106	0.2564	1
Brugia malayi	hypothetical protein	0.0049	0.0786	0.2559
Leishmania major	ATP-dependent phosphofructokinase	0.0106	0.2564	1
Brugia malayi	Latrophilin receptor protein 2	0.0032	0.0248	0.031
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0034	0.0318	0.0147

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 697471