Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | matrix metallopeptidase 1 (interstitial collagenase) | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Matrixin family protein | matrix metallopeptidase 1 (interstitial collagenase) | 403 aa | 401 aa | 27.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Legumain homolog | 0.119 | 1 | 1 |
Trichomonas vaginalis | Clan CD, family C13, legumain-like cysteine peptidase | 0.119 | 1 | 1 |
Trichomonas vaginalis | Clan CD, family C13, legumain-like cysteine peptidase | 0.119 | 1 | 1 |
Entamoeba histolytica | GPI-anchor transamidase, putative | 0.0276 | 0.1924 | 0.5 |
Plasmodium vivax | GPI-anchor transamidase, putative | 0.0276 | 0.1924 | 0.5 |
Toxoplasma gondii | peptidase c13 family protein | 0.0276 | 0.1924 | 0.5 |
Trypanosoma brucei | GPI-anchor transamidase subunit 8 (GPI8) | 0.0276 | 0.1924 | 0.5 |
Schistosoma mansoni | family C13 non-peptidase homologue (C13 family) | 0.119 | 1 | 1 |
Plasmodium falciparum | GPI-anchor transamidase, putative | 0.0276 | 0.1924 | 0.5 |
Schistosoma mansoni | hemoglobinase (C13 family) | 0.119 | 1 | 1 |
Loa Loa (eye worm) | peptidase C13 family protein | 0.119 | 1 | 1 |
Echinococcus granulosus | GPI anchor transamidase | 0.0276 | 0.1924 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0276 | 0.1924 | 0.1924 |
Loa Loa (eye worm) | matrixin family protein | 0.0064 | 0.0046 | 0.0046 |
Trypanosoma cruzi | cysteine peptidase, Clan CD, family C13, putative | 0.0276 | 0.1924 | 0.5 |
Trichomonas vaginalis | Clan CD, family C13, legumain-like cysteine peptidase | 0.119 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0914 | 0.756 | 0.6979 |
Trichomonas vaginalis | Clan CD, family C13, legumain-like cysteine peptidase | 0.119 | 1 | 1 |
Echinococcus multilocularis | GPI anchor transamidase | 0.0276 | 0.1924 | 1 |
Giardia lamblia | GPI-anchor transamidase, putative | 0.0276 | 0.1924 | 0.5 |
Leishmania major | GPI-anchor transamidase subunit 8 (GPI8), putative | 0.0276 | 0.1924 | 0.5 |
Trichomonas vaginalis | Clan CD, family C13, legumain-like cysteine peptidase | 0.119 | 1 | 1 |
Trichomonas vaginalis | Clan CD, family C13, legumain-like cysteine peptidase | 0.119 | 1 | 1 |
Brugia malayi | GPI-anchor transamidase | 0.0276 | 0.1924 | 0.1887 |
Trichomonas vaginalis | Clan CD, family C13, legumain-like cysteine peptidase | 0.119 | 1 | 1 |
Schistosoma mansoni | hemoglobinase (C13 family) | 0.119 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.09 uM | Inhibitory activity against Matrix Metallo Proteinase-1(MMP-1) | ChEMBL. | No reference |
IC50 (binding) | = 0.09 uM | Inhibitory activity against Matrix Metallo Proteinase-1(MMP-1) | ChEMBL. | No reference |
IC50 (binding) | = 0.97 uM | Inhibitory activity against Matrix Metallo Proteinase-1(MMP-1) | ChEMBL. | No reference |
IC50 (binding) | = 0.97 uM | Inhibitory activity against Matrix Metallo Proteinase-1(MMP-1) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.