Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | ubiquitin conjugating enzyme E2 N | 0.004 | 0.6566 | 1 |
Trypanosoma cruzi | ubiquitin-conjugating enzyme E2, putative | 0.004 | 0.6566 | 1 |
Brugia malayi | hypothetical protein | 0.0017 | 0.0147 | 0.0147 |
Trypanosoma brucei | ubiquitin-protein ligase, putative | 0.004 | 0.6566 | 1 |
Loa Loa (eye worm) | ubiquitin conjugating enzyme protein 13 | 0.004 | 0.6566 | 0.6566 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.5371 | 0.5371 |
Entamoeba histolytica | ubiquitin-conjugating enzyme family protein | 0.004 | 0.6566 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.5371 | 0.8181 |
Trichomonas vaginalis | ubiquitin-conjugating enzyme E2, putative | 0.004 | 0.6566 | 0.5 |
Leishmania major | ubiquitin-conjugating enzyme e2, putative | 0.004 | 0.6566 | 1 |
Loa Loa (eye worm) | ubiquitin conjugating enzyme protein 13 | 0.004 | 0.6566 | 0.6566 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 1 | 1 |
Trypanosoma cruzi | ubiquitin-conjugating enzyme E2, putative | 0.004 | 0.6566 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.2768 | 0.2768 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.5371 | 0.5371 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 1 | 1 |
Plasmodium vivax | ubiquitin-conjugating enzyme E2 N, putative | 0.004 | 0.6566 | 1 |
Toxoplasma gondii | ubiquitin-conjugating enzyme subfamily protein | 0.004 | 0.6566 | 1 |
Brugia malayi | hypothetical protein | 0.0026 | 0.2768 | 0.2768 |
Trichomonas vaginalis | ubiquitin-conjugating enzyme E2, putative | 0.004 | 0.6566 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 1 | 1 |
Plasmodium falciparum | ubiquitin-conjugating enzyme E2 N, putative | 0.004 | 0.6566 | 1 |
Brugia malayi | Ubiquitin conjugating enzyme protein 13 | 0.004 | 0.6566 | 0.6566 |
Brugia malayi | ubiquitin conjugating enzyme protein 13 | 0.004 | 0.6566 | 0.6566 |
Echinococcus granulosus | ubiquitin conjugating enzyme E2 N | 0.004 | 0.6566 | 1 |
Schistosoma mansoni | ubiquitin conjugating enzyme 13 | 0.004 | 0.6566 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 100 uM | Inhibition of HIV1 YU2 gp120 binding to CD4 expressing Cf2Th-CD4/CCR5 cells assessed as inhibition of viral infection after 48 hrs | ChEMBL. | 21169023 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.