Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | 0.5859 | 1 | 1 |
Echinococcus granulosus | gamma secretase subunit aph 1 | 0.5859 | 1 | 1 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0239 | 0.0067 | 0.5 |
Echinococcus multilocularis | presenilin | 0.0239 | 0.0067 | 0.0026 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0239 | 0.0067 | 0.5 |
Schistosoma mansoni | alzheimer's disease beta-amyloid related | 0.0348 | 0.0259 | 0.0193 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.2283 | 0.3679 | 1 |
Trypanosoma brucei | Aph-1 protein, putative | 0.2283 | 0.3679 | 1 |
Brugia malayi | Presenilin family protein | 0.0239 | 0.0067 | 0.0026 |
Leishmania major | presenilin-like aspartic peptidase, putative,presenilin-like aspartic peptidase, clan AD, family A22A, putative | 0.0239 | 0.0067 | 0.5 |
Echinococcus granulosus | presenilin | 0.0239 | 0.0067 | 0.0026 |
Entamoeba histolytica | presenilin 1 peptidase, putative | 0.0239 | 0.0067 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0752 | 0.0973 | 0.0973 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0239 | 0.0067 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0404 | 0.0358 | 0.0358 |
Schistosoma mansoni | gamma-secretase subunit aph-1 | 0.5859 | 1 | 1 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.2283 | 0.3679 | 1 |
Loa Loa (eye worm) | gamma-secretase subunit pen-2 | 0.0225 | 0.0041 | 0.0041 |
Echinococcus multilocularis | gamma secretase subunit aph 1 | 0.5859 | 1 | 1 |
Brugia malayi | Amyloid A4 extracellular domain containing protein | 0.0954 | 0.133 | 0.1295 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Antibody stimulation (functional) | = 64 | Antibody stimulation by serum hemagglutinin titer over the titer for the infected placebo-treated control in shhep redblood cells at 100 mg/Kg of dose; value is 64/16 | ChEMBL. | 6644739 |
Reduction (functional) | = 92 % | Percent reduction in spleen weight in mice as compared to infected untreated controls at 200 mg/kg | ChEMBL. | 6644739 |
Reduction (functional) | = 92 % | Percent reduction in spleen weight in mice as compared to infected untreated controls at 200 mg/kg | ChEMBL. | 6644739 |
Survivors (functional) | = 6 | Efficacy against a lethal virus challenge with an interferon sensitive virus, columbia SK was evaluated 14 days postinfection (oral dosing) as number of mice survived out of 15 tested | ChEMBL. | 6644739 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.