Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | P2X receptor subunit | 0.0311 | 1 | 1 |
Schistosoma mansoni | P2X receptor subunit | 0.0311 | 1 | 1 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.009 | 0.1368 | 0.5 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.0311 | 1 | 1 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0311 | 1 | 1 |
Brugia malayi | celfurPC protein | 0.012 | 0.2519 | 0.4795 |
Echinococcus multilocularis | neuroendocrine convertase 2 | 0.0093 | 0.1487 | 0.0138 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0311 | 1 | 1 |
Echinococcus multilocularis | 0.012 | 0.2519 | 0.1334 | |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.3639 | 1 |
Schistosoma mansoni | subfamily S8B unassigned peptidase (S08 family) | 0.0148 | 0.3639 | 0.3396 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.009 | 0.1368 | 0.5 |
Loa Loa (eye worm) | endoprotease bli-4 | 0.0148 | 0.3639 | 1 |
Echinococcus granulosus | furin | 0.0148 | 0.3639 | 0.2631 |
Schistosoma mansoni | P2X receptor subunit | 0.0311 | 1 | 1 |
Schistosoma mansoni | P2X receptor subunit | 0.0311 | 1 | 1 |
Echinococcus granulosus | neuroendocrine convertase 2 | 0.0093 | 0.1487 | 0.0138 |
Giardia lamblia | High cysteine membrane protein Group 2 | 0.0055 | 0 | 0.5 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.0311 | 1 | 1 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0311 | 1 | 1 |
Brugia malayi | endoprotease bli-4 precursor | 0.0148 | 0.3639 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | 0 uM | Displacement of 3[H]Flunitrazepam from GABA-A central benzodiazepine receptor of bovine brain membranes (no data) | ChEMBL. | 2821257 |
Inhibition (binding) | = 10 % | Displacement of 3[H]Flunitrazepam from GABA-A central benzodiazepine receptor of bovine brain membranes at 34 uM | ChEMBL. | 2821257 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.