Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Histone deacetylase | 0.0137 | 0 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0137 | 0 | 0.5 |
Echinococcus multilocularis | histone deacetylase 3 | 0.0137 | 0 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0137 | 0 | 0.5 |
Echinococcus granulosus | histone deacetylase 3 | 0.0137 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 0 | 0.5 |
Schistosoma mansoni | histone deacetylase | 0.0137 | 0 | 0.5 |
Schistosoma mansoni | histone deacetylase | 0.0137 | 0 | 0.5 |
Leishmania major | methionine synthase, putative | 0.0679 | 0.0129 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0137 | 0 | 0.5 |
Echinococcus multilocularis | histone deacetylase 1 | 0.0137 | 0 | 0.5 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0137 | 0 | 0.5 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0137 | 0 | 0.5 |
Toxoplasma gondii | dihydropteroate synthase | 1.0399 | 0.2434 | 1 |
Plasmodium falciparum | hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase | 1.0399 | 0.2434 | 1 |
Brugia malayi | Histone deacetylase 1 | 0.0137 | 0 | 0.5 |
Mycobacterium tuberculosis | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FolK (7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase) ( | 3.2582 | 0.7695 | 1 |
Entamoeba histolytica | histone deacetylase, putative | 0.0137 | 0 | 0.5 |
Trypanosoma brucei | histone deacetylase 1 | 0.0137 | 0 | 0.5 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0137 | 0 | 0.5 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.0137 | 0 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0137 | 0 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0137 | 0 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0137 | 0 | 0.5 |
Brugia malayi | histone deacetylase 3 (HD3) | 0.0137 | 0 | 0.5 |
Plasmodium vivax | hydroxymethylpterin pyrophosphokinase-dihydropteroate synthetase, putative | 1.0399 | 0.2434 | 1 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.0137 | 0 | 0.5 |
Echinococcus granulosus | histone deacetylase 1 | 0.0137 | 0 | 0.5 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0137 | 0 | 0.5 |
Chlamydia trachomatis | bifunctional 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase/dihydropteroate synthase | 1.0399 | 0.2434 | 0.5 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0137 | 0 | 0.5 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0137 | 0 | 0.5 |
Mycobacterium ulcerans | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | 4.2302 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | 0 uM | Antiviral activity against Herpes simplex virus type 1 (HSV-1) up to 100 uM concentration; inactive | ChEMBL. | 2547068 |
IC50 (functional) | 0 uM | Antiviral activity against Human immunodeficiency virus 1 (HIV-1) up to 100 uM concentration; inactive | ChEMBL. | 2547068 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.