Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | glycylpeptide N tetradecanoyltransferase | 0.0178 | 1 | 1 |
Trypanosoma cruzi | N-myristoyl transferase, putative | 0.0178 | 1 | 1 |
Trichomonas vaginalis | N-myristoyl transferase, putative | 0.0178 | 1 | 1 |
Entamoeba histolytica | glycylpeptide N-tetradecanoyltransferase, putative | 0.0178 | 1 | 0.5 |
Echinococcus granulosus | glycylpeptide N tetradecanoyltransferase | 0.0178 | 1 | 1 |
Schistosoma mansoni | N-myristoyltransferase | 0.0178 | 1 | 0.5 |
Loa Loa (eye worm) | N-myristoyltransferase 2 | 0.0178 | 1 | 1 |
Giardia lamblia | CDC72 | 0.0178 | 1 | 0.5 |
Trypanosoma brucei | N-myristoyl transferase, putative | 0.0178 | 1 | 0.5 |
Trypanosoma brucei | N-myristoyltransferase | 0.0178 | 1 | 0.5 |
Trypanosoma cruzi | N-myristoyl transferase, putative | 0.0178 | 1 | 1 |
Plasmodium vivax | glycylpeptide N-tetradecanoyltransferase, putative | 0.0178 | 1 | 0.5 |
Leishmania major | N-myristoyl transferase, putative | 0.0178 | 1 | 1 |
Plasmodium falciparum | glycylpeptide N-tetradecanoyltransferase | 0.0178 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 ratio (functional) | = 2.8 | Antagonist activity against electrically stimulated guinea pig ileum using ethylketazocine (EK) as kappa opioid receptor agonist | ChEMBL. | 9171881 |
IC50 ratio (functional) | = 6.9 | Antagonist activity against electrically stimulated guinea pig ileum using morphine (M) as mu opioid receptor agonist | ChEMBL. | 9171881 |
IC50 ratio (functional) | = 1.7 | Antagonist selectivity ratio measured as delta IC50 to that of mu receptor IC50 values. | ChEMBL. | 9171881 |
IC50 ratio (functional) | = 2.8 | Antagonist activity against electrically stimulated guinea pig ileum using ethylketazocine (EK) as kappa opioid receptor agonist | ChEMBL. | 9171881 |
IC50 ratio (functional) | = 4.2 | Antagonist selectivity ratio measured as delta IC50 to that of mu kappa IC50 values. | ChEMBL. | 9171881 |
IC50 ratio (functional) | = 6.9 | Antagonist activity against electrically stimulated guinea pig ileum using morphine (M) as mu opioid receptor agonist | ChEMBL. | 9171881 |
IC50 ratio (functional) | = 11.8 | Compound was tested for the antagonist activity on the electrically stimulated mouse vas deferens using DADLE as delta opioid receptor agonist | ChEMBL. | 9171881 |
Max response (functional) | = -52 % | Compound was tested for agonistic activity on the electrically stimulated guinea pig ileum (GPI) at 1 microM | ChEMBL. | 9171881 |
Max response (functional) | = 0.6 % | Compound was tested for agonistic activity on the electrically stimulated mouse vas deferens (MVD) at 1 microM | ChEMBL. | 9171881 |
Max response (functional) | = 0.6 % | Compound was tested for agonistic activity on the electrically stimulated mouse vas deferens (MVD) at 1 microM | ChEMBL. | 9171881 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.