Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Ankyrin | 0.0014 | 0.0018 | 0.0018 |
Brugia malayi | hypothetical protein | 0.0064 | 0.7409 | 0.7409 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0082 | 1 | 1 |
Schistosoma mansoni | jun-related protein | 0.0066 | 0.774 | 1 |
Echinococcus granulosus | Ankyrin | 0.0014 | 0.0018 | 0.0018 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0082 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0066 | 0.774 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.9669 | 1 |
Echinococcus granulosus | jun protein | 0.0082 | 1 | 1 |
Echinococcus multilocularis | jun protein | 0.0082 | 1 | 1 |
Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.0072 | 0.8515 | 0.8515 |
Echinococcus granulosus | nuclear factor of activated T cells 5 | 0.0072 | 0.8515 | 0.8515 |
Schistosoma mansoni | retinoblastoma-binding protein 4 (rbbp4) | 0.0014 | 0.0018 | 0.0023 |
Onchocerca volvulus | 0.0064 | 0.7409 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.