Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0027 | 0.0073 | 1 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0027 | 0.0073 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0027 | 0.0073 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0027 | 0.0073 | 1 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0027 | 0.0073 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0027 | 0.0073 | 1 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0027 | 0.0073 | 1 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0027 | 0.0073 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0027 | 0.0073 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0027 | 0.0073 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0027 | 0.0073 | 1 |
Echinococcus multilocularis | carbonic anhydrase | 0.0027 | 0.0073 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0027 | 0.0073 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0011 | 0 | 0.5 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0027 | 0.0073 | 1 |
Mycobacterium tuberculosis | Malate synthase G GlcB | 0.2203 | 1 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0011 | 0 | 0.5 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0027 | 0.0073 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0027 | 0.0073 | 0.5 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0027 | 0.0073 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0011 | 0 | 0.5 |
Plasmodium falciparum | carbonic anhydrase | 0.0027 | 0.0073 | 0.5 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0027 | 0.0073 | 0.5 |
Leishmania major | carbonic anhydrase-like protein | 0.0027 | 0.0073 | 0.5 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0027 | 0.0073 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0027 | 0.0073 | 1 |
Echinococcus granulosus | carbonic anhydrase II | 0.0027 | 0.0073 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0027 | 0.0073 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0073 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0027 | 0.0073 | 1 |
Onchocerca volvulus | 0.0011 | 0 | 0.5 | |
Echinococcus multilocularis | carbonic anhydrase | 0.0027 | 0.0073 | 1 |
Schistosoma mansoni | carbonic anhydrase | 0.0027 | 0.0073 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0073 | 1 |
Echinococcus multilocularis | carbonic anhydrase | 0.0027 | 0.0073 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0027 | 0.0073 | 1 |
Mycobacterium ulcerans | malate synthase G | 0.2203 | 1 | 0.5 |
Echinococcus granulosus | carbonic anhydrase | 0.0027 | 0.0073 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0073 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0027 | 0.0073 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 11 uM | In vitro antihelminthic activity using AF2 Neuropeptide receptor binding assay in Caenorhabditis elegans | ChEMBL. | 10397509 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.