Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.4237 | 0.4237 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.2496 | 0.2496 |
Brugia malayi | hypothetical protein | 0.003 | 0.4237 | 0.4237 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.5256 | 0.5256 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0023 | 0.2496 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.4237 | 0.5 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0017 | 0.1148 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.1148 | 0.1148 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.4237 | 1 |
Onchocerca volvulus | 0.0023 | 0.2496 | 1 | |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 1 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.2496 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.5256 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.5256 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.4237 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.5256 | 0.5256 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.4237 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.2496 | 0.2496 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 1 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.4237 | 0.5 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.2496 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0023 | 0.2496 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 1 | 1 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0017 | 0.1148 | 0.139 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.2496 | 0.2496 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.5256 | 0.5256 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.1148 | 0.1148 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.5256 | 1 |
Brugia malayi | hypothetical protein | 0.002 | 0.173 | 0.173 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.2496 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.2496 | 0.2496 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.2496 | 0.2496 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.2496 | 0.5 |
Brugia malayi | hypothetical protein | 0.0035 | 0.5256 | 0.5256 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.2496 | 0.2496 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.2496 | 0.5 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.003 | 0.4237 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.1148 | 0.1148 |
Mycobacterium ulcerans | hypothetical protein | 0.0023 | 0.2496 | 1 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0023 | 0.2496 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.1148 | 0.1148 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.4237 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0023 | 0.2496 | 1 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0014 | 0.0336 | 0.0336 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0023 | 0.2496 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.4237 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.5256 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.1148 | 0.1148 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0014 | 0.0336 | 0.0336 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.5256 | 0.5256 |
Schistosoma mansoni | hypothetical protein | 0.0014 | 0.0336 | 0.0336 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0023 | 0.2496 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 12.5893 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.