Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0003 | 0.0017 | 0.0067 |
Leishmania major | hypothetical protein, conserved | 0.0003 | 0 | 0.5 |
Schistosoma mansoni | NADH dehydrogenase subunit 1 | 0.0039 | 0.2529 | 0.2529 |
Trypanosoma cruzi | Voltage-dependent calcium channel subunit, putative | 0.0003 | 0 | 0.5 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0003 | 0.00000011473 | 0.0001 |
Schistosoma mansoni | transient receptor potential channel | 0.0003 | 0.00000011473 | 0.00000011473 |
Toxoplasma gondii | 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein | 0.0003 | 0 | 0.5 |
Toxoplasma gondii | 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein | 0.0003 | 0 | 0.5 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0003 | 0.0017 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0003 | 0.00000011473 | 0.00000045363 |
Trypanosoma brucei | inositol 1,4,5-trisphosphate receptor | 0.0003 | 0 | 0.5 |
Brugia malayi | olfactory channel protein osm-9 | 0.0003 | 0.0017 | 0.0067 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0003 | 0 | 0.5 |
Toxoplasma gondii | transporter, cation channel family protein | 0.0003 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0039 | 0.2529 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0003 | 0 | 0.5 |
Schistosoma mansoni | transient receptor potential channel | 0.0003 | 0.0017 | 0.0017 |
Leishmania major | calcium channel protein, putative,ion transporter, putative | 0.0003 | 0 | 0.5 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0003 | 0.00000011473 | 0.00000011473 |
Brugia malayi | NADH dehydrogenase subunit 1 | 0.0039 | 0.2529 | 1 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0003 | 0.0017 | 0.0017 |
Brugia malayi | NADH dehydrogenase subunit 1, identical | 0.0039 | 0.2529 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0144 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | NADH dehydrogenase subunit H | 0.0144 | 1 | 0.5 |
Onchocerca volvulus | 0.0039 | 0.2529 | 1 | |
Schistosoma mansoni | transient receptor potential channel | 0.0003 | 0.00000011473 | 0.00000011473 |
Mycobacterium ulcerans | NADH dehydrogenase subunit H | 0.0144 | 1 | 1 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0003 | 0.0017 | 0.0017 |
Toxoplasma gondii | transporter, cation channel family protein | 0.0003 | 0 | 0.5 |
Trypanosoma brucei | Voltage-dependent calcium channel subunit, putative | 0.0003 | 0 | 0.5 |
Leishmania major | hypothetical protein, unknown function | 0.0003 | 0 | 0.5 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0003 | 0.0017 | 1 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0003 | 0.0017 | 0.9999 |
Trypanosoma cruzi | inositol 1,4,5-trisphosphate receptor, putative | 0.0003 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase I (chain H) NuoH (NADH-ubiquinone oxidoreductase chain H) | 0.0144 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0003 | 0 | 0.5 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0003 | 0.00000011473 | 0.00000011473 |
Onchocerca volvulus | 0.0039 | 0.2529 | 1 | |
Toxoplasma gondii | hypothetical protein | 0.0003 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0003 | 0.00000011473 | 0.00000045363 |
Loa Loa (eye worm) | NADH dehydrogenase subunit 1 | 0.0039 | 0.2529 | 1 |
Toxoplasma gondii | transporter, cation channel family protein | 0.0003 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.