Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | SEA domain containing protein | 0.0006 | 0.0026 | 0.0026 |
Brugia malayi | Trypsin family protein | 0.0039 | 0.1117 | 0.1117 |
Onchocerca volvulus | 0.0006 | 0.0026 | 0.0235 | |
Schistosoma mansoni | hypothetical protein | 0.0007 | 0.0042 | 0.0134 |
Onchocerca volvulus | 0.0036 | 0.1011 | 0.9048 | |
Schistosoma mansoni | tyrosine kinase | 0.0097 | 0.302 | 0.9758 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0.0042 | 0.0042 |
Onchocerca volvulus | 0.0006 | 0.0026 | 0.0235 | |
Onchocerca volvulus | 0.0007 | 0.0042 | 0.0372 | |
Brugia malayi | hypothetical protein | 0.0007 | 0.0042 | 0.0042 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1117 | 0.1117 |
Onchocerca volvulus | 0.0006 | 0.0026 | 0.0235 | |
Onchocerca volvulus | 0.0006 | 0.0026 | 0.0235 | |
Brugia malayi | Protein kinase domain containing protein | 0.0007 | 0.0063 | 0.0063 |
Schistosoma mansoni | hypothetical protein | 0.0007 | 0.0042 | 0.0134 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0026 | 0.0026 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0.0042 | 0.0042 |
Echinococcus granulosus | MAM | 0.0007 | 0.0042 | 0.0134 |
Loa Loa (eye worm) | DOMON domain-containing protein | 0.0006 | 0.0026 | 0.0026 |
Loa Loa (eye worm) | hypothetical protein | 0.0309 | 1 | 1 |
Loa Loa (eye worm) | NNMT/PNMT/TEMT family protein | 0.0309 | 1 | 1 |
Onchocerca volvulus | 0.0006 | 0.0026 | 0.0235 | |
Loa Loa (eye worm) | TK/ALK protein kinase | 0.0007 | 0.0063 | 0.0063 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0026 | 0.0026 |
Onchocerca volvulus | 0.0039 | 0.1117 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0.0042 | 0.0042 |
Echinococcus multilocularis | tyrosine protein kinase shark | 0.0099 | 0.3095 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0006 | 0.0026 | 0.0085 |
Brugia malayi | Muscle positioning protein 4 | 0.0006 | 0.0026 | 0.0026 |
Echinococcus multilocularis | MAM | 0.0007 | 0.0042 | 0.0134 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1117 | 0.1117 |
Onchocerca volvulus | 0.0007 | 0.0042 | 0.0372 | |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0039 | 0.1117 | 0.3609 |
Schistosoma mansoni | tyrosine kinase | 0.0099 | 0.3095 | 1 |
Echinococcus granulosus | tyrosine protein kinase shark | 0.0099 | 0.3095 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0309 | 1 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0041 | 0.1191 | 0.3849 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.