Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.2344 | 0.5 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.2344 | 0.2344 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.2344 | 0.5 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.2344 | 0.5 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0019 | 0.2344 | 0.2344 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0019 | 0.2344 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0006 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0063 | 1 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.2344 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0063 | 1 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.2344 | 0.2344 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0019 | 0.2344 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 1 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0019 | 0.2344 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0.2344 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0063 | 1 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0019 | 0.2344 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 1 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0006 | 0 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.2344 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 1 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0019 | 0.2344 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0063 | 1 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0019 | 0.2344 | 0.2344 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0019 | 0.2344 | 0.5 |
Onchocerca volvulus | 0.0006 | 0 | 0.5 | |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0006 | 0 | 0.5 |
Toxoplasma gondii | exonuclease III APE | 0.0019 | 0.2344 | 0.5 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0019 | 0.2344 | 0.2344 |
Echinococcus granulosus | tar DNA binding protein | 0.0063 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0063 | 1 | 1 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.2344 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0063 | 1 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0.2344 | 0.5 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0.2344 | 0.2344 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | > 4 mg kg-1 | Antagonistic activity against apomorphine induced climbing in CD-1 mice, after oral administration | ChEMBL. | 6644744 |
ED50 (functional) | > 4 mg kg-1 | Antagonistic activity against apomorphine induced climbing in CD-1 mice, after oral administration | ChEMBL. | 6644744 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.