Detailed information for compound 719089

Basic information

Technical information
  • TDR Targets ID: 719089
  • Name: 1-(2,5-dichlorophenyl)-3-(2-fluorophenyl)thio urea
  • MW: 315.193 | Formula: C13H9Cl2FN2S
  • H donors: 2 H acceptors: 0 LogP: 4.44 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: S=C(Nc1cc(Cl)ccc1Cl)Nc1ccccc1F
  • InChi: 1S/C13H9Cl2FN2S/c14-8-5-6-9(15)12(7-8)18-13(19)17-11-4-2-1-3-10(11)16/h1-7H,(H2,17,18,19)
  • InChiKey: YJEZGXUURSFGCK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • STK135734
  • ZINC00619707

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni DNA polymerase zeta catalytic subunit 0.0076 0.1354 0.0534
Schistosoma mansoni hypothetical protein 0.0165 0.4929 0.6008
Leishmania major DNA polymerase delta catalytic subunit, putative 0.023 0.7536 1
Toxoplasma gondii DNA polymerase 0.023 0.7536 1
Trichomonas vaginalis DNA polymerase zeta catalytic subunit, putative 0.023 0.7536 1
Schistosoma mansoni DNA polymerase alpha catalytic subunit 0.0076 0.1354 0.0534
Onchocerca volvulus DNA polymerase delta catalytic subunit homolog 0.023 0.7536 1
Loa Loa (eye worm) hypothetical protein 0.025 0.8319 0.8319
Echinococcus multilocularis muscleblind protein 1 0.0292 1 1
Loa Loa (eye worm) hypothetical protein 0.0292 1 1
Plasmodium falciparum DNA polymerase delta catalytic subunit 0.023 0.7536 1
Echinococcus granulosus geminin 0.0165 0.4929 0.4135
Loa Loa (eye worm) DNA-directed DNA polymerase III 0.023 0.7536 0.7536
Echinococcus multilocularis DNA polymerase delta catalytic subunit 0.023 0.7536 0.715
Brugia malayi DNA polymerase family B containing protein 0.0076 0.1354 0.0388
Brugia malayi DNA polymerase alpha catalytic subunit 0.0076 0.1354 0.0388
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0182 0.5623 0.4937
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.1906 0.0638
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.1906 0.1379
Echinococcus multilocularis muscleblind protein 0.0292 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.1906 0.1379
Echinococcus granulosus muscleblind protein 0.0292 1 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.2253 0.1387
Trypanosoma brucei DNA polymerase delta catalytic subunit, putative 0.023 0.7536 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.1906 0.0638
Brugia malayi DNA polymerase family B, exonuclease domain containing protein 0.0076 0.1354 0.0388
Trypanosoma cruzi DNA polymerase delta catalytic subunit, putative 0.0188 0.5846 0.7266
Giardia lamblia DNA polymerase delta, catalytic subunit 0.023 0.7536 1
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0076 0.1354 0.1797
Loa Loa (eye worm) hypothetical protein 0.0292 1 1
Schistosoma mansoni DNA polymerase epsilon catalytic subunit 0.0076 0.1354 0.0534
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.1906 0.0638
Echinococcus granulosus DNA polymerase delta catalytic subunit 0.023 0.7536 0.715
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0076 0.1354 0.1797
Schistosoma mansoni hypothetical protein 0.0165 0.4929 0.6008
Schistosoma mansoni DNA polymerase delta catalytic subunit 0.023 0.7536 1
Trichomonas vaginalis DNA polymerase delta catalytic subunit, putative 0.0076 0.1354 0.1797
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.2253 0.2253
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.1906 0.0638
Brugia malayi DNA polymerase delta catalytic subunit 0.023 0.7536 0.726
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.009 0.1906 0.1906
Trichomonas vaginalis DNA polymerase II, putative 0.0076 0.1354 0.1797
Entamoeba histolytica DNA polymerase delta catalytic subunit, putative 0.023 0.7536 0.5
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.009 0.1906 0.1001
Loa Loa (eye worm) hypothetical protein 0.0067 0.1006 0.1006
Echinococcus multilocularis geminin 0.0165 0.4929 0.4135
Plasmodium vivax DNA polymerase delta catalytic subunit, putative 0.023 0.7536 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.025 0.8319 0.8131
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0182 0.5623 0.4937
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.1906 0.1379
Trypanosoma cruzi DNA polymerase delta catalytic subunit, putative 0.023 0.7536 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.1354 0.1354

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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