Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0044 | 0.2523 | 0.2523 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0134 | 0.9115 | 0.9115 |
Giardia lamblia | Cathepsin B precursor | 0.0044 | 0.2523 | 0.5 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0134 | 0.9115 | 0.9115 |
Echinococcus multilocularis | carbonic anhydrase | 0.0054 | 0.3258 | 0.3258 |
Onchocerca volvulus | 0.001 | 0 | 0.5 | |
Echinococcus multilocularis | cathepsin b | 0.0134 | 0.9115 | 0.9115 |
Echinococcus granulosus | carbonic anhydrase | 0.0054 | 0.3258 | 0.3258 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.001 | 0 | 0.5 |
Schistosoma mansoni | carbonic anhydrase | 0.0054 | 0.3258 | 0.3258 |
Echinococcus granulosus | cathepsin b | 0.0134 | 0.9115 | 0.9115 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0054 | 0.3258 | 0.3258 |
Giardia lamblia | Cathepsin B precursor | 0.0044 | 0.2523 | 0.5 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0146 | 1 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0146 | 1 | 1 |
Plasmodium falciparum | carbonic anhydrase | 0.0054 | 0.3258 | 0.5 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0054 | 0.3258 | 0.3258 |
Giardia lamblia | Cathepsin B precursor | 0.0044 | 0.2523 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase | 0.0054 | 0.3258 | 0.3258 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0146 | 1 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0054 | 0.3258 | 0.3258 |
Echinococcus granulosus | cathepsin b | 0.0134 | 0.9115 | 0.9115 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0054 | 0.3258 | 0.3258 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0054 | 0.3258 | 0.3258 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0054 | 0.3258 | 0.3258 |
Echinococcus multilocularis | carbonic anhydrase | 0.0054 | 0.3258 | 0.3258 |
Onchocerca volvulus | Bile acid receptor homolog | 0.001 | 0 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0146 | 1 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0134 | 0.9115 | 0.9115 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0146 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.3258 | 0.3258 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0134 | 0.9115 | 0.9115 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0146 | 1 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0054 | 0.3258 | 0.3258 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.3258 | 0.3258 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0054 | 0.3258 | 0.3258 |
Brugia malayi | cathepsin B-like cysteine proteinase | 0.0134 | 0.9115 | 0.9115 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.9115 | 0.9115 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.3258 | 0.3258 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0044 | 0.2523 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0146 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0134 | 0.9115 | 0.8817 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0134 | 0.9115 | 0.9115 |
Schistosoma mansoni | hypothetical protein | 0.0054 | 0.3258 | 0.3258 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.001 | 0 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0054 | 0.3258 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0054 | 0.3258 | 0.3258 |
Loa Loa (eye worm) | cathepsin B | 0.0044 | 0.2523 | 0.2523 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0054 | 0.3258 | 0.3258 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0054 | 0.3258 | 0.3258 |
Echinococcus granulosus | carbonic anhydrase II | 0.0146 | 1 | 1 |
Leishmania major | carbonic anhydrase-like protein | 0.0146 | 1 | 1 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0146 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0146 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.