Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | jun protein | 0.0099 | 1 | 1 |
Onchocerca volvulus | 0.0078 | 0.6675 | 1 | |
Echinococcus multilocularis | jun protein | 0.0099 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.008 | 0.7099 | 1 |
Schistosoma mansoni | jun-related protein | 0.008 | 0.7099 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0099 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0078 | 0.6675 | 0.6675 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0099 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.9576 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Change (functional) | = -60 % | Hypoglycemic activity in blood glucose at 2 hr (treated) in the fasted-refed rat | ChEMBL. | 4068003 |
Change (functional) | = -59 % | Hypoglycemic activity in blood glucose at 2 hr (treated) in the 18-h fasted normal rat at a dose of 100 mg/kg | ChEMBL. | 4068003 |
Change (functional) | = -40 % | Hypoglycemic activity in blood glucose at 2 hr (positive control) in the fasted-refed rat | ChEMBL. | 4068003 |
Change (functional) | = -39 % | Hypoglycemic activity in blood glucose at 2 hr (positive control) in the 18-h fasted normal rat | ChEMBL. | 4068003 |
Relative potency (functional) | = 13 | Hypoglycemic activity in the 18-h fasted normal rat with respect to 1-butyl-3-(p-tolylsulfonyl)urea | ChEMBL. | 4068003 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.