Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.1125 | 0.912 | 1 |
Loa Loa (eye worm) | glutamate receptor | 0.0389 | 0.2162 | 0.2162 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.1218 | 1 | 1 |
Loa Loa (eye worm) | metabotropic GABA-B receptor subtype 2 | 0.0254 | 0.088 | 0.088 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0482 | 0.3042 | 0.3881 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0829 | 0.6319 | 0.6319 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.099 | 0.7838 | 1 |
Onchocerca volvulus | Poor gastrulation protein homolog | 0.0161 | 0 | 0.5 |
Onchocerca volvulus | Metabotropic glutamate receptor homolog | 0.0161 | 0 | 0.5 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.0254 | 0.088 | 0.1122 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0829 | 0.6319 | 0.6319 |
Loa Loa (eye worm) | receptor family ligand binding region containing protein | 0.0254 | 0.088 | 0.088 |
Loa Loa (eye worm) | hypothetical protein | 0.0254 | 0.088 | 0.088 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0482 | 0.3042 | 0.3335 |
Loa Loa (eye worm) | glutamate receptor | 0.099 | 0.7838 | 0.7838 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0897 | 0.6958 | 0.8878 |
Loa Loa (eye worm) | hypothetical protein | 0.1218 | 1 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0829 | 0.6319 | 0.6929 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 7 % | Glutathione peroxidase-like activity in relative to Ebselen glutathione peroxidase-like activity | ChEMBL. | 10794693 |
Activity (functional) | = 44 uM | Glutathione peroxidase-like activity at 10x(E -4) M concentration measured as NADP+/L/min | ChEMBL. | 10794693 |
Activity (functional) | = 44 uM | Glutathione peroxidase-like activity at 10x(E -4) M concentration measured as NADP+/L/min | ChEMBL. | 10794693 |
Activity (functional) | = 71 uM | Glutathione peroxidase-like activity at 10x(E -3) M concentration as NADP+/L/min | ChEMBL. | 10794693 |
Activity (functional) | = 75 uM | Glutathione peroxidase-like activity at 10x(E -2) M concentration as NADP+/L/min | ChEMBL. | 10794693 |
Effective molarity (functional) | = 0.00001 M l-1 | Antioxidative property against stable murine-murine hybridoma (Mark 3) cell line | ChEMBL. | 10794693 |
Effective molarity (functional) | = 0.00001 M l-1 | Antioxidative property against stable murine-murine hybridoma (Mark 3) cell line | ChEMBL. | 10794693 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.