Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Glutamate NMDA receptor | Starlite/ChEMBL | References |
Homo sapiens | glutamate receptor, ionotropic, N-methyl D-aspartate 1 | Starlite/ChEMBL | References |
Rattus norvegicus | Glutamate (NMDA) receptor subunit zeta 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Drosophila melanogaster | Glutamate receptor IA | Glutamate (NMDA) receptor subunit zeta 1 | 938 aa | 979 aa | 23.7 % |
Drosophila melanogaster | NMDA receptor 2 | Glutamate (NMDA) receptor subunit zeta 1 | 938 aa | 878 aa | 27.4 % |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | Glutamate (NMDA) receptor subunit zeta 1 | 938 aa | 822 aa | 23.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | nmda type glutamate receptor | 0.0204 | 0.6898 | 0.1893 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0204 | 0.6898 | 0.6898 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0263 | 1 | 1 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.019 | 0.6174 | 0.6174 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0246 | 0.9112 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5.91 uM | Tested for the ability to inhibit [3H]-MK-801 binding to NMDA receptor of rat cortical membranes in the presence of glutamate (1 microM) | ChEMBL. | No reference |
IC50 (binding) | = 5.91 uM | Tested for the ability to inhibit [3H]-MK-801 binding to NMDA receptor of rat cortical membranes in the presence of glutamate (1 microM) | ChEMBL. | No reference |
IC50 (binding) | = 6 uM | Activity against rat cortical and hippocampal membrane strychnine-insensitive N-methyl-D-aspartate glutamate receptor 1 using [3H]-gly | ChEMBL. | 2146391 |
IC50 (binding) | = 6 uM | Ability to compete with [3H]-glycine for strychnine-insensitive binding sites on rat cortical and hippocampal membrane | ChEMBL. | 1534125 |
IC50 (binding) | = 6 uM | Activity against rat cortical and hippocampal membrane strychnine-insensitive N-methyl-D-aspartate glutamate receptor 1 using [3H]-gly | ChEMBL. | 2146391 |
IC50 (binding) | = 6 uM | Ability to compete with [3H]-glycine for strychnine-insensitive binding sites on rat cortical and hippocampal membrane | ChEMBL. | 1534125 |
IC50 (binding) | > 1000 uM | Activity against rat cortical and hippocampal membrane N-methyl-D-aspartate glutamate receptor 1/2A/2B/2C/2D using [3H]-CPP | ChEMBL. | 2146391 |
IC50 (binding) | > 1000 uM | Ability to compete with [3H]-CCP for rat cortical and hippocampal membrane glutamate binding site. | ChEMBL. | 1534125 |
IC50 (binding) | > 1000 uM | Activity against rat cortical and hippocampal membrane N-methyl-D-aspartate glutamate receptor 1/2A/2B/2C/2D using [3H]-CPP | ChEMBL. | 2146391 |
Ki (binding) | = 0.98 uM | Tested for the ability to displace [3H]-glycine, by greater than 50%, from NMDA receptor of rat cortical membranes at a dose of 10 microM | ChEMBL. | No reference |
Ki (binding) | = 0.98 uM | Tested for the ability to displace [3H]-glycine, by greater than 50%, from NMDA receptor of rat cortical membranes at a dose of 10 microM | ChEMBL. | No reference |
Ki (binding) | = 2.9 uM | Tested for the affinity for the glycine binding site of the N-methyl-D-aspartate glutamate receptor using pig brain membranes in binding assay with [3H]-MDL- 105,519 | ChEMBL. | 12502360 |
Ki (binding) | = 2.9 uM | Tested for the affinity for the glycine binding site of the N-methyl-D-aspartate glutamate receptor using pig brain membranes in binding assay with [3H]-MDL- 105,519 | ChEMBL. | 12502360 |
Ratio (binding) | > 150 | Ratio of the inhibitory activity against [3H]-CCP for rat cortical and hippocampal membrane glutamate binding site to [3H]-glycine for rat cortical and hippocampal membrane binding site. | ChEMBL. | 1534125 |
Ratio (binding) | > 150 | Selectivity ratio for CPP and gly NMDA binding | ChEMBL. | 2146391 |
Ratio (binding) | > 150 | Ratio of the inhibitory activity against [3H]-CCP for rat cortical and hippocampal membrane glutamate binding site to [3H]-glycine for rat cortical and hippocampal membrane binding site. | ChEMBL. | 1534125 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.