Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | neuropeptide Y receptor Y1 | Starlite/ChEMBL | References |
Homo sapiens | neuropeptide Y receptor Y5 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | follicle stimulating hormone receptor | neuropeptide Y receptor Y1 | 384 aa | 345 aa | 22.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0202 | 1 | 1 |
Leishmania major | p450 reductase, putative | 0.0202 | 1 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0202 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0202 | 1 | 1 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0202 | 1 | 1 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0202 | 1 | 1 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0179 | 0.7709 | 0.5 |
Chlamydia trachomatis | sulfite reductase | 0.0124 | 0.2291 | 0.5 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0202 | 1 | 0.5 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0202 | 1 | 0.5 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0202 | 1 | 1 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0202 | 1 | 0.5 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0202 | 1 | 1 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0202 | 1 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0202 | 1 | 0.5 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0202 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0202 | 1 | 0.5 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0202 | 1 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0179 | 0.7709 | 0.5 |
Trypanosoma cruzi | p450 reductase, putative | 0.0202 | 1 | 0.5 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0202 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0202 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0202 | 1 | 1 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0124 | 0.2291 | 0.2291 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0202 | 1 | 0.5 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0202 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 10 nM | Tested for radioligand binding affinity against membranes from COS-7 cells transiently transfected with Neuropeptide Y receptor type 5 | ChEMBL. | 12067557 |
Ki (binding) | = 10 nM | Tested for radioligand binding affinity against membranes from COS-7 cells transiently transfected with Neuropeptide Y receptor type 5 | ChEMBL. | 12067557 |
Ki (binding) | = 12981 nM | Tested for radioligand binding affinity against membranes from COS-7 cells transiently transfected with Neuropeptide Y receptor type 1 | ChEMBL. | 12067557 |
Ki (binding) | = 12981 nM | Tested for radioligand binding affinity against membranes from COS-7 cells transiently transfected with Neuropeptide Y receptor type 1 | ChEMBL. | 12067557 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.