Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0093 | 0.0562 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0279 | 0.2852 | 0.2749 |
Plasmodium falciparum | endoplasmic reticulum oxidoreductin, putative | 0.0059 | 0.0142 | 0.5 |
Schistosoma mansoni | ero1-related | 0.0059 | 0.0142 | 0.0181 |
Loa Loa (eye worm) | hypothetical protein | 0.0176 | 0.1589 | 0.1468 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0093 | 0.0562 | 0.5 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0679 | 0.7769 | 0.7737 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0093 | 0.0562 | 0.0426 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0093 | 0.0562 | 1 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0082 | 0.0425 | 0.0543 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0093 | 0.0562 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0632 | 0.7187 | 0.7147 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0093 | 0.0562 | 0.5 |
Toxoplasma gondii | endoplasmic reticulum oxidoreductin, putative | 0.0059 | 0.0142 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0121 | 0.0904 | 0.0773 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0093 | 0.0562 | 0.0426 |
Brugia malayi | hypothetical protein | 0.0176 | 0.1589 | 0.1468 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0093 | 0.0562 | 0.5 |
Schistosoma mansoni | calcium-activated potassium channel | 0.0632 | 0.7187 | 0.9179 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0093 | 0.0562 | 0.5 |
Echinococcus granulosus | small conductance calcium activated potassium | 0.0632 | 0.7187 | 0.7147 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.0082 | 0.0425 | 0.0287 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0094 | 0.058 | 1 |
Trypanosoma brucei | polo-like protein kinase | 0.0093 | 0.0562 | 1 |
Brugia malayi | Kelch motif family protein | 0.0176 | 0.1589 | 0.1468 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0425 | 0.0287 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0082 | 0.0425 | 0.0287 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0679 | 0.7769 | 0.9923 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0093 | 0.0562 | 0.0426 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0094 | 0.058 | 1 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0093 | 0.0562 | 1 |
Echinococcus granulosus | integrin beta 2 | 0.086 | 1 | 1 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0093 | 0.0562 | 0.5 |
Giardia lamblia | Kinase, PLK | 0.0093 | 0.0562 | 0.5 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0094 | 0.058 | 1 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0094 | 0.058 | 1 |
Brugia malayi | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 0.0082 | 0.0425 | 0.0287 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0093 | 0.0562 | 0.0426 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0093 | 0.0562 | 0.0718 |
Loa Loa (eye worm) | integrin beta-2 | 0.086 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0093 | 0.0562 | 0.5 |
Echinococcus multilocularis | integrin beta 2 | 0.086 | 1 | 1 |
Echinococcus multilocularis | small conductance calcium activated potassium | 0.0632 | 0.7187 | 0.7147 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0679 | 0.7769 | 0.7737 |
Schistosoma mansoni | integrin beta subunit | 0.0684 | 0.783 | 1 |
Loa Loa (eye worm) | kelch domain-containing protein family protein | 0.0176 | 0.1589 | 0.1468 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0093 | 0.0562 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0093 | 0.0562 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0632 | 0.7187 | 0.9179 |
Loa Loa (eye worm) | hypothetical protein | 0.0205 | 0.1936 | 0.182 |
Plasmodium vivax | endoplasmic reticulum oxidoreductin, putative | 0.0059 | 0.0142 | 0.5 |
Schistosoma mansoni | calcium-activated potassium channel | 0.0484 | 0.5369 | 0.6857 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.