Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Cavia porcellus | Histamine H3 receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | neuropeptides capa receptor | Histamine H3 receptor | 445 aa | 441 aa | 20.4 % |
Echinococcus granulosus | biogenic amine 5HT receptor | Histamine H3 receptor | 445 aa | 412 aa | 23.8 % |
Loa Loa (eye worm) | hypothetical protein | Histamine H3 receptor | 445 aa | 386 aa | 23.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | voltage-gated potassium channel | 0.0049 | 0.1734 | 1 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.0102 | 1 | 1 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0045 | 0.1101 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0102 | 1 | 0.5 |
Onchocerca volvulus | 0.0037 | 0 | 0.5 | |
Onchocerca volvulus | 0.0037 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.019 | 0.019 |
Onchocerca volvulus | 0.0037 | 0 | 0.5 | |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0045 | 0.1101 | 0.1101 |
Onchocerca volvulus | 0.0037 | 0 | 0.5 | |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0.0647 | 0.5 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0037 | 0 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0049 | 0.1734 | 1 |
Onchocerca volvulus | 0.0037 | 0 | 0.5 | |
Onchocerca volvulus | 0.0037 | 0 | 0.5 | |
Onchocerca volvulus | 0.0037 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 1 | 1 |
Onchocerca volvulus | 0.0037 | 0 | 0.5 | |
Onchocerca volvulus | 0.0037 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 1 | 1 |
Onchocerca volvulus | 0.0037 | 0 | 0.5 | |
Onchocerca volvulus | 0.0037 | 0 | 0.5 | |
Onchocerca volvulus | 0.0037 | 0 | 0.5 | |
Onchocerca volvulus | 0.0037 | 0 | 0.5 | |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0045 | 0.1101 | 1 |
Onchocerca volvulus | 0.0037 | 0 | 0.5 | |
Onchocerca volvulus | 0.0037 | 0 | 0.5 | |
Onchocerca volvulus | 0.0037 | 0 | 0.5 | |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0045 | 0.1101 | 1 |
Onchocerca volvulus | 0.0037 | 0 | 0.5 | |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0037 | 0 | 0.5 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0.0647 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Kd (functional) | = 6.25 | In vitro histamine H3 receptor antagonist activity was determined on guinea pig jejunum | ChEMBL. | 10794692 |
pA2 (functional) | = 6.25 | In vitro histamine H3 receptor antagonist activity was determined on guinea pig jejunum | ChEMBL. | 10794692 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.