Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.0719 | 0.1093 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.01 | 0.3367 | 0.3367 |
Toxoplasma gondii | aspartyl protease ASP1 | 0.0048 | 0 | 0.5 |
Echinococcus granulosus | jun protein | 0.01 | 0.3367 | 0.3367 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0143 | 0.6136 | 0.6136 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0143 | 0.6136 | 0.6136 |
Schistosoma mansoni | hypothetical protein | 0.0081 | 0.2147 | 0.2147 |
Brugia malayi | Carboxylesterase family protein | 0.0149 | 0.6579 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0202 | 1 | 1 |
Echinococcus multilocularis | jun protein | 0.01 | 0.3367 | 0.3367 |
Plasmodium falciparum | plasmepsin IV | 0.0048 | 0 | 0.5 |
Plasmodium vivax | aspartyl proteinase, putative | 0.0048 | 0 | 0.5 |
Onchocerca volvulus | 0.0079 | 0.1968 | 0.5 | |
Plasmodium falciparum | plasmepsin I | 0.0048 | 0 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0059 | 0.0719 | 0.1093 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.3189 | 0.4847 |
Toxoplasma gondii | aspartyl proteinase (eimepsin), putative | 0.0048 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.6579 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.01 | 0.3367 | 0.3367 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0149 | 0.6579 | 0.6579 |
Plasmodium vivax | plasmepsin IV, putative | 0.0048 | 0 | 0.5 |
Brugia malayi | bZIP transcription factor family protein | 0.01 | 0.3367 | 0.4519 |
Trichomonas vaginalis | Clan AA, family A1, cathepsin D-like aspartic peptidase | 0.0048 | 0 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0149 | 0.6579 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0149 | 0.6579 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0149 | 0.6579 | 0.6579 |
Echinococcus granulosus | carboxylesterase 5A | 0.0149 | 0.6579 | 0.6579 |
Echinococcus granulosus | acetylcholinesterase | 0.0149 | 0.6579 | 0.6579 |
Echinococcus multilocularis | geminin | 0.0202 | 1 | 1 |
Plasmodium falciparum | plasmepsin II | 0.0048 | 0 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0149 | 0.6579 | 0.6579 |
Brugia malayi | Carboxylesterase family protein | 0.0149 | 0.6579 | 1 |
Schistosoma mansoni | jun-related protein | 0.0081 | 0.2147 | 0.2147 |
Echinococcus multilocularis | acetylcholinesterase | 0.0149 | 0.6579 | 0.6579 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.6579 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0202 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0079 | 0.1968 | 0.2131 |
Echinococcus multilocularis | acetylcholinesterase | 0.0149 | 0.6579 | 0.6579 |
Plasmodium falciparum | plasmepsin VI | 0.0048 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Concentration (functional) | ND 0 % | Reduction of Astrocyte intracellular chloride concentration at 1 mM; No data. | ChEMBL. | 3656355 |
Concentration (functional) | = 76 % | Reduction of Astrocyte intracellular chloride concentration at 0.05 mM. | ChEMBL. | 3656355 |
Concentration (functional) | = 104 % | Reduction of Astrocyte intracellular chloride concentration at 0.1 mM. | ChEMBL. | 3656355 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.