Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0027 | 0 | 0.5 |
Echinococcus granulosus | carbonic anhydrase | 0.0027 | 0 | 0.5 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0027 | 0 | 0.5 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0027 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0 | 0.5 |
Trichomonas vaginalis | dihydrodipicolinate synthase, putative | 0.0113 | 0.0386 | 0.5 |
Chlamydia trachomatis | 4-hydroxy-tetrahydrodipicolinate synthase | 0.0113 | 0.0386 | 0.5 |
Mycobacterium ulcerans | malate synthase G | 0.2253 | 1 | 1 |
Plasmodium falciparum | carbonic anhydrase | 0.0027 | 0 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0027 | 0 | 0.5 |
Mycobacterium tuberculosis | Malate synthase G GlcB | 0.2253 | 1 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0027 | 0 | 0.5 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0027 | 0 | 0.5 |
Schistosoma mansoni | carbonic anhydrase | 0.0027 | 0 | 0.5 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0027 | 0 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0027 | 0 | 0.5 |
Leishmania major | carbonic anhydrase-like protein | 0.0027 | 0 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase | 0.0027 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydrodipicolinate synthase | 0.0113 | 0.0386 | 0.5 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0027 | 0 | 0.5 |
Toxoplasma gondii | dihydrodipicolinate synthase | 0.0113 | 0.0386 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0027 | 0 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase | 0.0027 | 0 | 0.5 |
Echinococcus granulosus | carbonic anhydrase | 0.0027 | 0 | 0.5 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0027 | 0 | 0.5 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0027 | 0 | 0.5 |
Echinococcus granulosus | carbonic anhydrase | 0.0027 | 0 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase | 0.0027 | 0 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0027 | 0 | 0.5 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0027 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0 | 0.5 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0027 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0027 | 0 | 0.5 |
Echinococcus granulosus | carbonic anhydrase II | 0.0027 | 0 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0027 | 0 | 0.5 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0027 | 0 | 0.5 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0027 | 0 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0027 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 24 uM | Ability to inhibit platelet aggregation | ChEMBL. | 11459636 |
IC50 (functional) | > 24 uM | Ability to inhibit platelet aggregation | ChEMBL. | 11459636 |
IC50 (binding) | > 50 uM | Ability to displace [3H]-2-MeS-ADP from human Purinergic receptor P2Y12 | ChEMBL. | 11459636 |
IC50 (binding) | > 50 uM | Ability to displace [3H]-2-MeS-ADP from human Purinergic receptor P2Y12 | ChEMBL. | 11459636 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.