Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0167 | 0.6702 | 0.7601 |
Schistosoma mansoni | hypothetical protein | 0.0182 | 0.7621 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0116 | 0.3788 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.6702 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0116 | 0.3788 | 0.0984 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0167 | 0.6702 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0116 | 0.3788 | 0.5 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0167 | 0.6702 | 0.7837 |
Entamoeba histolytica | hypothetical protein | 0.0116 | 0.3788 | 0.5 |
Brugia malayi | Probable ClpP-like protease | 0.0167 | 0.6702 | 1 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0167 | 0.6702 | 1 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0167 | 0.6702 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0167 | 0.6702 | 0.5 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0167 | 0.6702 | 0.5 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0167 | 0.6702 | 1 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0167 | 0.6702 | 1 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0167 | 0.6702 | 1 |
Brugia malayi | hypothetical protein | 0.0116 | 0.3788 | 0.5652 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.0109 | 0.3369 | 0.4744 |
Echinococcus granulosus | geminin | 0.0182 | 0.7621 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0116 | 0.3788 | 0.5 |
Echinococcus multilocularis | geminin | 0.0182 | 0.7621 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0116 | 0.3788 | 0.0984 |
Schistosoma mansoni | hypothetical protein | 0.0182 | 0.7621 | 1 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0167 | 0.6702 | 1 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0167 | 0.6702 | 0.5 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0167 | 0.6702 | 1 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0167 | 0.6702 | 0.7837 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.