Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | ERV/ALR sulfhydryl oxidase domain-containing protein | 0.0068 | 1 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0 | 0.5 |
Trypanosoma brucei | ERV/ALR sulfhydryl oxidase domain-containing protein | 0.0068 | 1 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0 | 0.5 |
Loa Loa (eye worm) | hepatopoietin HPO2 | 0.0068 | 1 | 1 |
Trypanosoma cruzi | Present in the outer mitochondrial membrane proteome 4 | 0.0068 | 1 | 0.5 |
Toxoplasma gondii | Erv1 / Alr family protein | 0.0068 | 1 | 0.5 |
Plasmodium vivax | FAD-linked sulfhydryl oxidase ERV1, putative | 0.0068 | 1 | 0.5 |
Plasmodium falciparum | FAD-linked sulfhydryl oxidase ERV1, putative | 0.0068 | 1 | 0.5 |
Trypanosoma cruzi | Present in the outer mitochondrial membrane proteome 4 | 0.0068 | 1 | 0.5 |
Echinococcus granulosus | FAD linked sulfhydryl oxidase ALR | 0.0068 | 1 | 1 |
Echinococcus multilocularis | FAD linked sulfhydryl oxidase ALR | 0.0068 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0 | 0.5 |
Toxoplasma gondii | Erv1 / Alr family protein | 0.0068 | 1 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0068 | 1 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.