Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0038 | 0.5111 | 0.5111 |
Brugia malayi | hypothetical protein | 0.0038 | 0.5111 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.5111 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0011 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0063 | 1 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0063 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0011 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0011 | 0 | 0.5 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0063 | 1 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0011 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.5111 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0011 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0011 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.5111 | 0.5111 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0063 | 1 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0063 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0063 | 1 | 0.5 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0063 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.5111 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.5111 | 0.5 |
Onchocerca volvulus | 0.0011 | 0 | 0.5 | |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0063 | 1 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0038 | 0.5111 | 0.5111 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0011 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0063 | 1 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0011 | 0 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0011 | 0 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0038 | 0.5111 | 0.5111 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0011 | 0 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0011 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.