Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | DNA-directed RNA polymerase I | 0.00927523 | 1 | 1 |
Brugia malayi | RNA polymerase Rpb1, domain 2 family protein | 0.00927523 | 1 | 1 |
Giardia lamblia | RNA polymerase AI large subunit | 0.00927523 | 1 | 1 |
Trypanosoma brucei | DNA-directed RNA polymerase III subunit C1 | 0.00308512 | 0.234905 | 0.257116 |
Trypanosoma cruzi | DNA-directed rna polymerase I largest subunit, putative | 0.00857632 | 0.913615 | 1 |
Chlamydia trachomatis | DNA-directed RNA polymerase subunit beta' | 0.00308512 | 0.234905 | 0.5 |
Schistosoma mansoni | DNA-directed RNA polymerase II largest subunit | 0.00308512 | 0.234905 | 0.22879 |
Trypanosoma brucei | DNA-directed RNA polymerase III largest subunit, putative | 0.00190053 | 0.0884894 | 0.0968564 |
Plasmodium vivax | DNA-directed RNA polymerase I 190 kDa polypeptide, putative | 0.00927523 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.00927523 | 1 | 1 |
Toxoplasma gondii | DNA-directed RNA polymerase II RPB1 | 0.00308512 | 0.234905 | 0.234905 |
Plasmodium falciparum | DNA-directed RNA polymerase II subunit RPB1 | 0.00308512 | 0.234905 | 0.22879 |
Toxoplasma gondii | DNA-directed RNA polymerase I RPA1 | 0.00927523 | 1 | 1 |
Trypanosoma brucei | DNA-directed RNA polymerase I largest subunit | 0.00857632 | 0.913615 | 1 |
Trypanosoma brucei | DNA-directed rna polymerase I largest subunit, putative | 0.00857632 | 0.913615 | 1 |
Leishmania major | DNA-directed rna polymerase I largest subunit, putative | 0.00857632 | 0.913615 | 1 |
Trypanosoma brucei | RNA polymerase IIA largest subunit | 0.00308512 | 0.234905 | 0.257116 |
Trichomonas vaginalis | DNA-directed RNA polymerase I largest subunit, putative | 0.00308512 | 0.234905 | 0.250612 |
Mycobacterium leprae | DNA-DIRECTED RNA POLYMERASE (BETA' CHAIN) RPOC (TRANSCRIPTASE BETA' CHAIN) (RNA POLYMERASE BETA' SUBUNIT). | 0.00308512 | 0.234905 | 0.5 |
Treponema pallidum | DNA-directed RNA polymerase subunit beta' | 0.00308512 | 0.234905 | 0.5 |
Plasmodium falciparum | DNA-directed RNA polymerase III subunit RPC1, putative | 0.00308512 | 0.234905 | 0.22879 |
Toxoplasma gondii | DNA-directed RNA polymerase III RPC1 | 0.00308512 | 0.234905 | 0.234905 |
Plasmodium falciparum | RNA polymerase I | 0.00927523 | 1 | 1 |
Echinococcus granulosus | DNA directed RNA polymerase I subunit RPA1 | 0.00857632 | 0.913615 | 1 |
Schistosoma mansoni | RNA polymerase Rpb1 | 0.00308512 | 0.234905 | 0.22879 |
Trichomonas vaginalis | RNA polymerase A, putative | 0.00857632 | 0.913615 | 1 |
Echinococcus multilocularis | DNA directed RNA polymerase I subunit RPA1 | 0.00857632 | 0.913615 | 1 |
Mycobacterium ulcerans | DNA-directed RNA polymerase subunit beta' | 0.00308512 | 0.234905 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | DNA-directed RNA polymerase subunit beta/beta' | 0.00308512 | 0.234905 | 0.5 |
Trypanosoma brucei | DNA-directed RNA polymerase II subunit RPB1 | 0.00308512 | 0.234905 | 0.257116 |
Trichomonas vaginalis | DNA-directed RNA polymerase I largest subunit, putative | 0.00308512 | 0.234905 | 0.250612 |
Entamoeba histolytica | DNA-directed RNA polymerase I largest subunit, putative | 0.00927523 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 8.08 uM | Plasmodium falciparum 3D7 EC50 (uM) as measured by SYBR green dye | Saint Jude. | 20485428 |
EC50 (functional) | 8.0841 uM | ST_JUDE: Plasmodium falciparum 3D7 EC50 (uM) as measured by SYBR green dye | ChEMBL. | 20485428 |
EC50 (functional) | = 15 uM | Plasmodium falciparum K1 EC50 (uM) as measured by SYBR green dye | Saint Jude. | 20485428 |
EC50 (functional) | > 15 uM | ST_JUDE: Plasmodium falciparum K1 EC50 (uM) as measured by SYBR green dye | ChEMBL. | 20485428 |
Percent growth inhibition (functional) | = 85.8 % | Plasmodium falciparum 3D7 % growth inhibition at 7uM as measured by YOYO-3 red dye | Saint Jude. | 20485428 |
Percent growth inhibition (functional) | = 101.7 % | Plasmodium falciparum 3D7 % growth inhibition at 7uM as measured by SYBR green dye | Saint Jude. | 20485428 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 20485428 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.